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Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior

The paraventricular thalamic nucleus (PVT) is a part of epithalamus and sends outputs to emotion-related brain areas such as the medial prefrontal cortex, nucleus accumbens, and amygdala. Various functional roles of the PVT in emotion-related behaviors are drawing attention. Here, we investigated th...

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Autores principales: Kato, Tomoaki M., Fujimori-Tonou, Noriko, Mizukami, Hiroaki, Ozawa, Keiya, Fujisawa, Shigeyoshi, Kato, Tadafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848207/
https://www.ncbi.nlm.nih.gov/pubmed/31712646
http://dx.doi.org/10.1038/s41598-019-52984-y
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author Kato, Tomoaki M.
Fujimori-Tonou, Noriko
Mizukami, Hiroaki
Ozawa, Keiya
Fujisawa, Shigeyoshi
Kato, Tadafumi
author_facet Kato, Tomoaki M.
Fujimori-Tonou, Noriko
Mizukami, Hiroaki
Ozawa, Keiya
Fujisawa, Shigeyoshi
Kato, Tadafumi
author_sort Kato, Tomoaki M.
collection PubMed
description The paraventricular thalamic nucleus (PVT) is a part of epithalamus and sends outputs to emotion-related brain areas such as the medial prefrontal cortex, nucleus accumbens, and amygdala. Various functional roles of the PVT in emotion-related behaviors are drawing attention. Here, we investigated the effect of manipulation of PVT neurons on the firing patterns of medial prefrontal cortical (mPFC) neurons and depression-like behavior. Extracellular single-unit recordings revealed that acute activation of PVT neurons by hM3Dq, an activation type of designer receptors exclusively activated by designer drugs (DREADDs), and administration of clozapine N-oxide (CNO) caused firing rate changes in mPFC neurons. Moreover, chronic presynaptic inhibition in PVT neurons by tetanus toxin (TeTX) increased the proportion of interneurons among firing neurons in mPFC and shortened the immobility time in the forced swimming test, whereas long-term activation of PVT neurons by hM3Dq caused recurrent hypoactivity episodes. These findings suggest that PVT neurons regulate the excitation/inhibition balance in the mPFC and mood stability.
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spelling pubmed-68482072019-11-19 Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior Kato, Tomoaki M. Fujimori-Tonou, Noriko Mizukami, Hiroaki Ozawa, Keiya Fujisawa, Shigeyoshi Kato, Tadafumi Sci Rep Article The paraventricular thalamic nucleus (PVT) is a part of epithalamus and sends outputs to emotion-related brain areas such as the medial prefrontal cortex, nucleus accumbens, and amygdala. Various functional roles of the PVT in emotion-related behaviors are drawing attention. Here, we investigated the effect of manipulation of PVT neurons on the firing patterns of medial prefrontal cortical (mPFC) neurons and depression-like behavior. Extracellular single-unit recordings revealed that acute activation of PVT neurons by hM3Dq, an activation type of designer receptors exclusively activated by designer drugs (DREADDs), and administration of clozapine N-oxide (CNO) caused firing rate changes in mPFC neurons. Moreover, chronic presynaptic inhibition in PVT neurons by tetanus toxin (TeTX) increased the proportion of interneurons among firing neurons in mPFC and shortened the immobility time in the forced swimming test, whereas long-term activation of PVT neurons by hM3Dq caused recurrent hypoactivity episodes. These findings suggest that PVT neurons regulate the excitation/inhibition balance in the mPFC and mood stability. Nature Publishing Group UK 2019-11-11 /pmc/articles/PMC6848207/ /pubmed/31712646 http://dx.doi.org/10.1038/s41598-019-52984-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kato, Tomoaki M.
Fujimori-Tonou, Noriko
Mizukami, Hiroaki
Ozawa, Keiya
Fujisawa, Shigeyoshi
Kato, Tadafumi
Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
title Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
title_full Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
title_fullStr Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
title_full_unstemmed Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
title_short Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
title_sort presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848207/
https://www.ncbi.nlm.nih.gov/pubmed/31712646
http://dx.doi.org/10.1038/s41598-019-52984-y
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