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The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review

African Americans have double the prevalence of Alzheimer’s disease (AD), as compared to European Americans. However, the underlying causes of this health disparity are due to a multitude of environmental, lifestyle, and genetic factors that are not yet fully understood. Here, we review the effects...

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Detalles Bibliográficos
Autores principales: Berg, Chelsie N., Sinha, Neha, Gluck, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848225/
https://www.ncbi.nlm.nih.gov/pubmed/31749691
http://dx.doi.org/10.3389/fnhum.2019.00387
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author Berg, Chelsie N.
Sinha, Neha
Gluck, Mark A.
author_facet Berg, Chelsie N.
Sinha, Neha
Gluck, Mark A.
author_sort Berg, Chelsie N.
collection PubMed
description African Americans have double the prevalence of Alzheimer’s disease (AD), as compared to European Americans. However, the underlying causes of this health disparity are due to a multitude of environmental, lifestyle, and genetic factors that are not yet fully understood. Here, we review the effects of the two largest genetic risk factors for AD in African Americans: Apolipoprotein E (APOE) and ABCA7. We will describe the direct effects of genetic variation on neural correlates of cognitive function and report the indirect modulating effects of genetic variation on modifiable AD risk factors, such as aerobic fitness. As a means of integrating previous findings, we present a novel schematic diagram to illustrate the many factors that contribute to AD risk and impaired cognitive function in older African Americans. Finally, we discuss areas that require further inquiry, and stress the importance of racially diverse and representative study populations.
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spelling pubmed-68482252019-11-20 The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review Berg, Chelsie N. Sinha, Neha Gluck, Mark A. Front Hum Neurosci Human Neuroscience African Americans have double the prevalence of Alzheimer’s disease (AD), as compared to European Americans. However, the underlying causes of this health disparity are due to a multitude of environmental, lifestyle, and genetic factors that are not yet fully understood. Here, we review the effects of the two largest genetic risk factors for AD in African Americans: Apolipoprotein E (APOE) and ABCA7. We will describe the direct effects of genetic variation on neural correlates of cognitive function and report the indirect modulating effects of genetic variation on modifiable AD risk factors, such as aerobic fitness. As a means of integrating previous findings, we present a novel schematic diagram to illustrate the many factors that contribute to AD risk and impaired cognitive function in older African Americans. Finally, we discuss areas that require further inquiry, and stress the importance of racially diverse and representative study populations. Frontiers Media S.A. 2019-11-05 /pmc/articles/PMC6848225/ /pubmed/31749691 http://dx.doi.org/10.3389/fnhum.2019.00387 Text en Copyright © 2019 Berg, Sinha and Gluck. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Berg, Chelsie N.
Sinha, Neha
Gluck, Mark A.
The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review
title The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review
title_full The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review
title_fullStr The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review
title_full_unstemmed The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review
title_short The Effects of APOE and ABCA7 on Cognitive Function and Alzheimer’s Disease Risk in African Americans: A Focused Mini Review
title_sort effects of apoe and abca7 on cognitive function and alzheimer’s disease risk in african americans: a focused mini review
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848225/
https://www.ncbi.nlm.nih.gov/pubmed/31749691
http://dx.doi.org/10.3389/fnhum.2019.00387
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