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Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population

Many studies have tried to elucidate the connection between vitamin D receptor (VDR) gene (ApaI) polymorphism and periodontitis; however, so far there is no consensus. To further assess the impact of ApaI polymorphism on periodontitis risk, we have conducted a meta‐analysis of Chinese population. Re...

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Autores principales: Guo, Hai‐xia, Pan, Jian, Pan, Heng‐biao, Cui, Si‐jia, Fang, Chun‐ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848803/
https://www.ncbi.nlm.nih.gov/pubmed/31763010
http://dx.doi.org/10.1002/fsn3.1215
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author Guo, Hai‐xia
Pan, Jian
Pan, Heng‐biao
Cui, Si‐jia
Fang, Chun‐ying
author_facet Guo, Hai‐xia
Pan, Jian
Pan, Heng‐biao
Cui, Si‐jia
Fang, Chun‐ying
author_sort Guo, Hai‐xia
collection PubMed
description Many studies have tried to elucidate the connection between vitamin D receptor (VDR) gene (ApaI) polymorphism and periodontitis; however, so far there is no consensus. To further assess the impact of ApaI polymorphism on periodontitis risk, we have conducted a meta‐analysis of Chinese population. Relevant literatures were searched according to PubMed and Chinese database in January 2019. The strength of correlation was evaluated by combining odds ratio (ORs) and 95% confidence interval (CIs). Six case–control studies were identified with inclusion criteria, including 734 cases of periodontitis and 687 controls. Based on the overall analysis, the VDR ApaI polymorphism was not due to the risk of periodontitis in all models. Subgroup analysis showed that the risk of periodontitis in North China was significantly reduced. To sum up, the study shows that VDR‐ApaI polymorphism may be connected with a lower risk of periodontitis in northern China. It is suggested that inferential studies should be conducted in other ethnic groups.
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spelling pubmed-68488032019-11-22 Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population Guo, Hai‐xia Pan, Jian Pan, Heng‐biao Cui, Si‐jia Fang, Chun‐ying Food Sci Nutr Original Research Many studies have tried to elucidate the connection between vitamin D receptor (VDR) gene (ApaI) polymorphism and periodontitis; however, so far there is no consensus. To further assess the impact of ApaI polymorphism on periodontitis risk, we have conducted a meta‐analysis of Chinese population. Relevant literatures were searched according to PubMed and Chinese database in January 2019. The strength of correlation was evaluated by combining odds ratio (ORs) and 95% confidence interval (CIs). Six case–control studies were identified with inclusion criteria, including 734 cases of periodontitis and 687 controls. Based on the overall analysis, the VDR ApaI polymorphism was not due to the risk of periodontitis in all models. Subgroup analysis showed that the risk of periodontitis in North China was significantly reduced. To sum up, the study shows that VDR‐ApaI polymorphism may be connected with a lower risk of periodontitis in northern China. It is suggested that inferential studies should be conducted in other ethnic groups. John Wiley and Sons Inc. 2019-09-27 /pmc/articles/PMC6848803/ /pubmed/31763010 http://dx.doi.org/10.1002/fsn3.1215 Text en © 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Guo, Hai‐xia
Pan, Jian
Pan, Heng‐biao
Cui, Si‐jia
Fang, Chun‐ying
Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population
title Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population
title_full Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population
title_fullStr Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population
title_full_unstemmed Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population
title_short Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population
title_sort correlation of vitamin d receptor gene (apai) polymorphism with periodontitis: a meta‐analysis of chinese population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848803/
https://www.ncbi.nlm.nih.gov/pubmed/31763010
http://dx.doi.org/10.1002/fsn3.1215
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