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Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual...

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Autores principales: Keller, Andreas, Ludwig, Nicole, Fehlmann, Tobias, Kahraman, Mustafa, Backes, Christina, Kern, Fabian, Vogelmeier, Claus F., Diener, Caroline, Fischer, Ulrike, Biertz, Frank, Herr, Christian, Jörres, Rudolf A., Lenhof, Hans-Peter, Bals, Robert, Meese, Eckart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848926/
https://www.ncbi.nlm.nih.gov/pubmed/31569706
http://dx.doi.org/10.3390/cells8101162
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author Keller, Andreas
Ludwig, Nicole
Fehlmann, Tobias
Kahraman, Mustafa
Backes, Christina
Kern, Fabian
Vogelmeier, Claus F.
Diener, Caroline
Fischer, Ulrike
Biertz, Frank
Herr, Christian
Jörres, Rudolf A.
Lenhof, Hans-Peter
Bals, Robert
Meese, Eckart
author_facet Keller, Andreas
Ludwig, Nicole
Fehlmann, Tobias
Kahraman, Mustafa
Backes, Christina
Kern, Fabian
Vogelmeier, Claus F.
Diener, Caroline
Fischer, Ulrike
Biertz, Frank
Herr, Christian
Jörres, Rudolf A.
Lenhof, Hans-Peter
Bals, Robert
Meese, Eckart
author_sort Keller, Andreas
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study “COPD and SYstemic consequences-COmorbidities NETwork” (COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n = 53) and patients that survived this period (n = 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients.
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spelling pubmed-68489262019-11-18 Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients Keller, Andreas Ludwig, Nicole Fehlmann, Tobias Kahraman, Mustafa Backes, Christina Kern, Fabian Vogelmeier, Claus F. Diener, Caroline Fischer, Ulrike Biertz, Frank Herr, Christian Jörres, Rudolf A. Lenhof, Hans-Peter Bals, Robert Meese, Eckart Cells Article Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study “COPD and SYstemic consequences-COmorbidities NETwork” (COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n = 53) and patients that survived this period (n = 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients. MDPI 2019-09-27 /pmc/articles/PMC6848926/ /pubmed/31569706 http://dx.doi.org/10.3390/cells8101162 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Keller, Andreas
Ludwig, Nicole
Fehlmann, Tobias
Kahraman, Mustafa
Backes, Christina
Kern, Fabian
Vogelmeier, Claus F.
Diener, Caroline
Fischer, Ulrike
Biertz, Frank
Herr, Christian
Jörres, Rudolf A.
Lenhof, Hans-Peter
Bals, Robert
Meese, Eckart
Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients
title Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients
title_full Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients
title_fullStr Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients
title_full_unstemmed Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients
title_short Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients
title_sort low mir-150-5p and mir-320b expression predicts reduced survival of copd patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848926/
https://www.ncbi.nlm.nih.gov/pubmed/31569706
http://dx.doi.org/10.3390/cells8101162
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