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Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli

Inflammatory macrophages play a critical role in gut and extra-gut inflammatory disorders, which may be promoted through the dysbiosis of gut microbiota. However, it is poorly understood how gut microbiota affect inflammatory macrophages. Here, we found that increased Escherichia coli (E. coli) in i...

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Autores principales: Qi, Houbao, Gao, Yunhuan, Li, Yuanyuan, Wei, Jianmei, Su, Xiaomin, Zhang, Chunze, Liu, Yingquan, Zhu, Hua, Sui, Lei, Xiong, Yanwen, Yang, Xi, Xu, Yanmei, Zhang, Yuan, Yang, Rongcun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849333/
https://www.ncbi.nlm.nih.gov/pubmed/31707260
http://dx.doi.org/10.1016/j.isci.2019.10.046
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author Qi, Houbao
Gao, Yunhuan
Li, Yuanyuan
Wei, Jianmei
Su, Xiaomin
Zhang, Chunze
Liu, Yingquan
Zhu, Hua
Sui, Lei
Xiong, Yanwen
Yang, Xi
Xu, Yanmei
Zhang, Yuan
Yang, Rongcun
author_facet Qi, Houbao
Gao, Yunhuan
Li, Yuanyuan
Wei, Jianmei
Su, Xiaomin
Zhang, Chunze
Liu, Yingquan
Zhu, Hua
Sui, Lei
Xiong, Yanwen
Yang, Xi
Xu, Yanmei
Zhang, Yuan
Yang, Rongcun
author_sort Qi, Houbao
collection PubMed
description Inflammatory macrophages play a critical role in gut and extra-gut inflammatory disorders, which may be promoted through the dysbiosis of gut microbiota. However, it is poorly understood how gut microbiota affect inflammatory macrophages. Here, we found that increased Escherichia coli (E. coli) in inflamed colon may induce inflammatory macrophages in gut and extra-gut tissues. These E. coli are different from other commensal and pathogenic E. coli in genomic components and also in ability to induce inflammatory responses. Dominant E. coli from colitic tissues induce gut inflammatory macrophages through a regulating network consisted of IL-18, IFN-γ, IL-12, and IL-22 in gut tissues. These E. coli also directly activate macrophages. Cytosolic inflammasome components PCKδ, NLRC4, caspase8, and caspase1/11 are involved in E. coli-mediated activation in both gut epithelial cells and macrophages. These disclose a novel mechanism for how dysbiosis of gut microbiota in colitis cause inflammatory macrophages related to multiple diseases.
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spelling pubmed-68493332019-11-15 Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli Qi, Houbao Gao, Yunhuan Li, Yuanyuan Wei, Jianmei Su, Xiaomin Zhang, Chunze Liu, Yingquan Zhu, Hua Sui, Lei Xiong, Yanwen Yang, Xi Xu, Yanmei Zhang, Yuan Yang, Rongcun iScience Article Inflammatory macrophages play a critical role in gut and extra-gut inflammatory disorders, which may be promoted through the dysbiosis of gut microbiota. However, it is poorly understood how gut microbiota affect inflammatory macrophages. Here, we found that increased Escherichia coli (E. coli) in inflamed colon may induce inflammatory macrophages in gut and extra-gut tissues. These E. coli are different from other commensal and pathogenic E. coli in genomic components and also in ability to induce inflammatory responses. Dominant E. coli from colitic tissues induce gut inflammatory macrophages through a regulating network consisted of IL-18, IFN-γ, IL-12, and IL-22 in gut tissues. These E. coli also directly activate macrophages. Cytosolic inflammasome components PCKδ, NLRC4, caspase8, and caspase1/11 are involved in E. coli-mediated activation in both gut epithelial cells and macrophages. These disclose a novel mechanism for how dysbiosis of gut microbiota in colitis cause inflammatory macrophages related to multiple diseases. Elsevier 2019-10-26 /pmc/articles/PMC6849333/ /pubmed/31707260 http://dx.doi.org/10.1016/j.isci.2019.10.046 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qi, Houbao
Gao, Yunhuan
Li, Yuanyuan
Wei, Jianmei
Su, Xiaomin
Zhang, Chunze
Liu, Yingquan
Zhu, Hua
Sui, Lei
Xiong, Yanwen
Yang, Xi
Xu, Yanmei
Zhang, Yuan
Yang, Rongcun
Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli
title Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli
title_full Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli
title_fullStr Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli
title_full_unstemmed Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli
title_short Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli
title_sort induction of inflammatory macrophages in the gut and extra-gut tissues by colitis-mediated escherichia coli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849333/
https://www.ncbi.nlm.nih.gov/pubmed/31707260
http://dx.doi.org/10.1016/j.isci.2019.10.046
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