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Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis

BACKGROUND: The aim of this study was to identify the nosocomial infection (NI) risk factors in neonatal Intensive Care Units (NICU). MATERIAL/METHODS: Databases (PubMed, Embase, Cochrane, VANFUN, CNKI, and VTTMS) were searched using index words to find relevant studies published before November 201...

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Autores principales: Wang, Li, Du, Ke-Ning, Zhao, Yan-Ling, Yu, Ya-Juan, Sun, Li, Jiang, Hong-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849370/
https://www.ncbi.nlm.nih.gov/pubmed/31675354
http://dx.doi.org/10.12659/MSM.917185
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author Wang, Li
Du, Ke-Ning
Zhao, Yan-Ling
Yu, Ya-Juan
Sun, Li
Jiang, Hong-Bo
author_facet Wang, Li
Du, Ke-Ning
Zhao, Yan-Ling
Yu, Ya-Juan
Sun, Li
Jiang, Hong-Bo
author_sort Wang, Li
collection PubMed
description BACKGROUND: The aim of this study was to identify the nosocomial infection (NI) risk factors in neonatal Intensive Care Units (NICU). MATERIAL/METHODS: Databases (PubMed, Embase, Cochrane, VANFUN, CNKI, and VTTMS) were searched using index words to find relevant studies published before November 2018. Meta-analyses of relative risk (RR) were performed for the identification of risk factors. RESULTS: Data from 22 cohort studies (2270 infants with and 21 605 infants without NI) were included in the meta-analysis. Infant weight of <2500 g (RR: 3.44, 95% CI: 2.31–5.11), gestational age of <37 weeks (RR: 3.85, 95% CI: 1.87–7.92), mechanical ventilation use (RR: 3.16, 95% CI: 2.21–4.50), venipuncture (RR: 3.01, 95% CI: 1.20–7.57), the incidence of asphyxia (RR: 1.68, 95% CI: 1.04–2.71), and feeding intolerance (RR: 2.12, 95% CI: 1.60–2.81) were identified as the risk factors for the incidence of NI. There was no significant publication bias. CONCLUSIONS: This study shows that <2500 g infant body weight, gestational age of <37 weeks, mechanical ventilation utility, venipuncture, asphyxia incidence, and feeding intolerance are the risk factors for NI nosocomial infection in infants in NICU. Appropriate preventive measures and targeted interventions are needed.
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spelling pubmed-68493702019-11-18 Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis Wang, Li Du, Ke-Ning Zhao, Yan-Ling Yu, Ya-Juan Sun, Li Jiang, Hong-Bo Med Sci Monit Meta-Analysis BACKGROUND: The aim of this study was to identify the nosocomial infection (NI) risk factors in neonatal Intensive Care Units (NICU). MATERIAL/METHODS: Databases (PubMed, Embase, Cochrane, VANFUN, CNKI, and VTTMS) were searched using index words to find relevant studies published before November 2018. Meta-analyses of relative risk (RR) were performed for the identification of risk factors. RESULTS: Data from 22 cohort studies (2270 infants with and 21 605 infants without NI) were included in the meta-analysis. Infant weight of <2500 g (RR: 3.44, 95% CI: 2.31–5.11), gestational age of <37 weeks (RR: 3.85, 95% CI: 1.87–7.92), mechanical ventilation use (RR: 3.16, 95% CI: 2.21–4.50), venipuncture (RR: 3.01, 95% CI: 1.20–7.57), the incidence of asphyxia (RR: 1.68, 95% CI: 1.04–2.71), and feeding intolerance (RR: 2.12, 95% CI: 1.60–2.81) were identified as the risk factors for the incidence of NI. There was no significant publication bias. CONCLUSIONS: This study shows that <2500 g infant body weight, gestational age of <37 weeks, mechanical ventilation utility, venipuncture, asphyxia incidence, and feeding intolerance are the risk factors for NI nosocomial infection in infants in NICU. Appropriate preventive measures and targeted interventions are needed. International Scientific Literature, Inc. 2019-11-01 /pmc/articles/PMC6849370/ /pubmed/31675354 http://dx.doi.org/10.12659/MSM.917185 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Meta-Analysis
Wang, Li
Du, Ke-Ning
Zhao, Yan-Ling
Yu, Ya-Juan
Sun, Li
Jiang, Hong-Bo
Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis
title Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis
title_full Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis
title_fullStr Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis
title_full_unstemmed Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis
title_short Risk Factors of Nosocomial Infection for Infants in Neonatal Intensive Care Units: A Systematic Review and Meta-Analysis
title_sort risk factors of nosocomial infection for infants in neonatal intensive care units: a systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849370/
https://www.ncbi.nlm.nih.gov/pubmed/31675354
http://dx.doi.org/10.12659/MSM.917185
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