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First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry

OBJECTIVE: We had developed compact rotating gantry for carbon ion using superconducting magnets in 2015 which became clinically operational in 2017. The objective of this study was to assess the clinical feasibility and safety of using compact rotating gantry with three-dimensional active scanning...

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Autores principales: Bhattacharyya, Tapesh, Koto, Masashi, Ikawa, Hiroaki, Hayashi, Kazuhiko, Hagiwara, Yasuhito, Makishima, Hirokazu, Kasuya, Goro, Yamamoto, Naoyoshi, Kamada, Tadashi, Tsuji, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849685/
https://www.ncbi.nlm.nih.gov/pubmed/31317764
http://dx.doi.org/10.1259/bjr.20190370
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author Bhattacharyya, Tapesh
Koto, Masashi
Ikawa, Hiroaki
Hayashi, Kazuhiko
Hagiwara, Yasuhito
Makishima, Hirokazu
Kasuya, Goro
Yamamoto, Naoyoshi
Kamada, Tadashi
Tsuji, Hiroshi
author_facet Bhattacharyya, Tapesh
Koto, Masashi
Ikawa, Hiroaki
Hayashi, Kazuhiko
Hagiwara, Yasuhito
Makishima, Hirokazu
Kasuya, Goro
Yamamoto, Naoyoshi
Kamada, Tadashi
Tsuji, Hiroshi
author_sort Bhattacharyya, Tapesh
collection PubMed
description OBJECTIVE: We had developed compact rotating gantry for carbon ion using superconducting magnets in 2015 which became clinically operational in 2017. The objective of this study was to assess the clinical feasibility and safety of using compact rotating gantry with three-dimensional active scanning in delivery of carbon-ion radiotherapy (C-ion RT) for relatively stationary tumours. METHODS: A prospective feasibility study was conducted with 10 patients who had been treated with C-ion RT using compact rotating gantry between April 2017 and April 2018 at Hospital of the National Institute of Radiological Sciences (NIRS) for head and neck and prostate cancers. The primary end point was evaluation of acute toxicities within 3 months of starting C-ion RT. RESULTS: Out of 10 cases 8 were of head and neck cancers and 2 were of prostate cancers. All of those eight head and neck cases were of locally advanced stages. Both of the prostate cancer patients belong to intermediate risk categories. None of the patients developed even Grade 2 or more severe skin reactions. Six out of eight cases with head and neck cancers experienced Grade 2 mucosal reactions; however, nobody developed Grade 3 or more severe mucosal reactions. There was no gastrointestinal reaction observed in prostate cancer patients. One patient developed Grade 2 genitourinary reaction. CONCLUSION: C-ion RT using compact rotating gantry and three-dimensional active scanning is a safe and feasible treatment for relatively less mobile tumours. ADVANCES IN KNOWLEDGE: This study will be the first step to establish the use of superconducting rotating gantry in C-ionRT in clinical setting paving the way for treating large number of patients and make it a standard of practice in the future.
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spelling pubmed-68496852020-11-01 First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry Bhattacharyya, Tapesh Koto, Masashi Ikawa, Hiroaki Hayashi, Kazuhiko Hagiwara, Yasuhito Makishima, Hirokazu Kasuya, Goro Yamamoto, Naoyoshi Kamada, Tadashi Tsuji, Hiroshi Br J Radiol Short Communication OBJECTIVE: We had developed compact rotating gantry for carbon ion using superconducting magnets in 2015 which became clinically operational in 2017. The objective of this study was to assess the clinical feasibility and safety of using compact rotating gantry with three-dimensional active scanning in delivery of carbon-ion radiotherapy (C-ion RT) for relatively stationary tumours. METHODS: A prospective feasibility study was conducted with 10 patients who had been treated with C-ion RT using compact rotating gantry between April 2017 and April 2018 at Hospital of the National Institute of Radiological Sciences (NIRS) for head and neck and prostate cancers. The primary end point was evaluation of acute toxicities within 3 months of starting C-ion RT. RESULTS: Out of 10 cases 8 were of head and neck cancers and 2 were of prostate cancers. All of those eight head and neck cases were of locally advanced stages. Both of the prostate cancer patients belong to intermediate risk categories. None of the patients developed even Grade 2 or more severe skin reactions. Six out of eight cases with head and neck cancers experienced Grade 2 mucosal reactions; however, nobody developed Grade 3 or more severe mucosal reactions. There was no gastrointestinal reaction observed in prostate cancer patients. One patient developed Grade 2 genitourinary reaction. CONCLUSION: C-ion RT using compact rotating gantry and three-dimensional active scanning is a safe and feasible treatment for relatively less mobile tumours. ADVANCES IN KNOWLEDGE: This study will be the first step to establish the use of superconducting rotating gantry in C-ionRT in clinical setting paving the way for treating large number of patients and make it a standard of practice in the future. The British Institute of Radiology. 2019-11 2019-10-19 /pmc/articles/PMC6849685/ /pubmed/31317764 http://dx.doi.org/10.1259/bjr.20190370 Text en © 2019 The Authors. Published by the British Institute of Radiology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License http://creativecommons.org/licenses/by-nc/4.0/, which permits unrestricted non-commercial reuse, provided the original author and source are credited.
spellingShingle Short Communication
Bhattacharyya, Tapesh
Koto, Masashi
Ikawa, Hiroaki
Hayashi, Kazuhiko
Hagiwara, Yasuhito
Makishima, Hirokazu
Kasuya, Goro
Yamamoto, Naoyoshi
Kamada, Tadashi
Tsuji, Hiroshi
First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry
title First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry
title_full First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry
title_fullStr First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry
title_full_unstemmed First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry
title_short First prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry
title_sort first prospective feasibility study of carbon-ion radiotherapy using compact superconducting rotating gantry
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849685/
https://www.ncbi.nlm.nih.gov/pubmed/31317764
http://dx.doi.org/10.1259/bjr.20190370
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