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Modeling therapy resistance via the EGFR signaling pathway

Mutations in KRAS are often associated with resistance to EGFR‐targeting antibody therapy. Using comprehensive systems analyses, GNB5 has been identified as a potential target to overcome therapy resistance targeting the EGFR signaling pathways, whereby the AKT signaling pathway (PI3K) rather than t...

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Detalles Bibliográficos
Autores principales:	Plattner, Christina, Hackl, Hubert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850018/ https://www.ncbi.nlm.nih.gov/pubmed/30892828 http://dx.doi.org/10.1111/febs.14809

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