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Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry
BACKGROUND: Romiplostim is a thrombopoietin‐mimetic peptibody for adult refractory chronic immune thrombocytopenia (ITP). We aimed to describe ITP patients receiving romiplostim, platelet counts and romiplostim usage in UK clinical practice. METHODS: This was a retrospective cohort study of patients...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850028/ https://www.ncbi.nlm.nih.gov/pubmed/30758874 http://dx.doi.org/10.1111/ejh.13221 |
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author | Doobaree, Indraraj Umesh Newland, Adrian McDonald, Vickie Nandigam, Raghava Mensah, Lesley Leroy, Sandrine Seesaghur, Anouchka Patel, Hitan Wetten, Sally Provan, Drew |
author_facet | Doobaree, Indraraj Umesh Newland, Adrian McDonald, Vickie Nandigam, Raghava Mensah, Lesley Leroy, Sandrine Seesaghur, Anouchka Patel, Hitan Wetten, Sally Provan, Drew |
author_sort | Doobaree, Indraraj Umesh |
collection | PubMed |
description | BACKGROUND: Romiplostim is a thrombopoietin‐mimetic peptibody for adult refractory chronic immune thrombocytopenia (ITP). We aimed to describe ITP patients receiving romiplostim, platelet counts and romiplostim usage in UK clinical practice. METHODS: This was a retrospective cohort study of patients in the UKITP Registry who received romiplostim between October 2009 and January 2015, including data up to 6 months before romiplostim initiation through follow‐up. RESULTS: Of 1440 patients in the UKITP Registry, 118 adults with primary ITP were eligible. Before romiplostim, 22% had splenectomy, 12% received platelet transfusion, 97% received ≥ 1 different ITP medication and 77% received ≥ 3. Most patients (73%) initiated romiplostim ≥ 1 year after ITP diagnosis (chronic phase). The mean duration of romiplostim treatment was 5.7 (SE 0.9) months, and the median was 1.4 months (IQR: 0.2, 6.5). Mean platelet count before romiplostim was 38 × 10(9)/L, rising to 103 × 10(9)/L within 1 month, and remaining 50‐150 × 10(9)/L through up to 3 years of follow‐up. After romiplostim, 4% of patients had splenectomy, 6% received platelet transfusion, and 57% received just one ITP medication other than romiplostim. CONCLUSION: The study provides valuable insights into the real‐world use of romiplostim in primary ITP in routine practice and highlighted the timing of romiplostim initiation at different ITP disease phases. |
format | Online Article Text |
id | pubmed-6850028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68500282019-11-15 Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry Doobaree, Indraraj Umesh Newland, Adrian McDonald, Vickie Nandigam, Raghava Mensah, Lesley Leroy, Sandrine Seesaghur, Anouchka Patel, Hitan Wetten, Sally Provan, Drew Eur J Haematol Original Articles BACKGROUND: Romiplostim is a thrombopoietin‐mimetic peptibody for adult refractory chronic immune thrombocytopenia (ITP). We aimed to describe ITP patients receiving romiplostim, platelet counts and romiplostim usage in UK clinical practice. METHODS: This was a retrospective cohort study of patients in the UKITP Registry who received romiplostim between October 2009 and January 2015, including data up to 6 months before romiplostim initiation through follow‐up. RESULTS: Of 1440 patients in the UKITP Registry, 118 adults with primary ITP were eligible. Before romiplostim, 22% had splenectomy, 12% received platelet transfusion, 97% received ≥ 1 different ITP medication and 77% received ≥ 3. Most patients (73%) initiated romiplostim ≥ 1 year after ITP diagnosis (chronic phase). The mean duration of romiplostim treatment was 5.7 (SE 0.9) months, and the median was 1.4 months (IQR: 0.2, 6.5). Mean platelet count before romiplostim was 38 × 10(9)/L, rising to 103 × 10(9)/L within 1 month, and remaining 50‐150 × 10(9)/L through up to 3 years of follow‐up. After romiplostim, 4% of patients had splenectomy, 6% received platelet transfusion, and 57% received just one ITP medication other than romiplostim. CONCLUSION: The study provides valuable insights into the real‐world use of romiplostim in primary ITP in routine practice and highlighted the timing of romiplostim initiation at different ITP disease phases. John Wiley and Sons Inc. 2019-03-07 2019-05 /pmc/articles/PMC6850028/ /pubmed/30758874 http://dx.doi.org/10.1111/ejh.13221 Text en © 2019 The Authors. European Journal of Haematology Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Doobaree, Indraraj Umesh Newland, Adrian McDonald, Vickie Nandigam, Raghava Mensah, Lesley Leroy, Sandrine Seesaghur, Anouchka Patel, Hitan Wetten, Sally Provan, Drew Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry |
title | Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry |
title_full | Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry |
title_fullStr | Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry |
title_full_unstemmed | Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry |
title_short | Primary immune thrombocytopenia (ITP) treated with romiplostim in routine clinical practice: retrospective study from the United Kingdom ITP Registry |
title_sort | primary immune thrombocytopenia (itp) treated with romiplostim in routine clinical practice: retrospective study from the united kingdom itp registry |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850028/ https://www.ncbi.nlm.nih.gov/pubmed/30758874 http://dx.doi.org/10.1111/ejh.13221 |
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