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Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease
OBJECTIVES: To report the long‐term results of the sentinel node (SN) approach in patients with clinical stage I testicular tumours in our facility. PATIENTS AND METHODS: We conducted an analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour (TGCT) and treated...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850062/ https://www.ncbi.nlm.nih.gov/pubmed/30417511 http://dx.doi.org/10.1111/bju.14618 |
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author | Blok, Joost M. Kerst, J. Martijn Vegt, Erik Brouwer, Oscar R. Meijer, Richard P. Bosch, J.L.H. Ruud Bex, Axel van der Poel, Henk G. Horenblas, Simon |
author_facet | Blok, Joost M. Kerst, J. Martijn Vegt, Erik Brouwer, Oscar R. Meijer, Richard P. Bosch, J.L.H. Ruud Bex, Axel van der Poel, Henk G. Horenblas, Simon |
author_sort | Blok, Joost M. |
collection | PubMed |
description | OBJECTIVES: To report the long‐term results of the sentinel node (SN) approach in patients with clinical stage I testicular tumours in our facility. PATIENTS AND METHODS: We conducted an analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour (TGCT) and treated with an SN procedure at our tertiary referral centre. SNs were identified using lymphoscintigraphy with or without single‐photo‐emission computed tomography with CT (SPECT/CT). Patients underwent laparoscopic retroperitoneal SN excision with inguinal orchiectomy. Patients with a tumour‐positive SN underwent adjuvant treatment. Follow‐up was conducted according to then‐current guidelines. RESULTS: In two patients, no SNs were visualized on scintigraphy. In the remaining 25 patients, a median (range) of 3 (1–4) SNs per patient were removed. Two patients showed no malignancy on histopathological examination of the testis. Of the 23 patients diagnosed with TGCT (16 seminomas, seven non‐seminomas), three (13.0%) had occult metastatic disease. All 23 patients were without evidence of disease at a median (range) follow‐up of 63.9 (29.0–143.4) months. CONCLUSION: The SN procedure allows early identification of patients with occult metastatic disease in clinical stage I TGCT, enabling early treatment. |
format | Online Article Text |
id | pubmed-6850062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68500622019-11-15 Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease Blok, Joost M. Kerst, J. Martijn Vegt, Erik Brouwer, Oscar R. Meijer, Richard P. Bosch, J.L.H. Ruud Bex, Axel van der Poel, Henk G. Horenblas, Simon BJU Int Urological Oncology OBJECTIVES: To report the long‐term results of the sentinel node (SN) approach in patients with clinical stage I testicular tumours in our facility. PATIENTS AND METHODS: We conducted an analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour (TGCT) and treated with an SN procedure at our tertiary referral centre. SNs were identified using lymphoscintigraphy with or without single‐photo‐emission computed tomography with CT (SPECT/CT). Patients underwent laparoscopic retroperitoneal SN excision with inguinal orchiectomy. Patients with a tumour‐positive SN underwent adjuvant treatment. Follow‐up was conducted according to then‐current guidelines. RESULTS: In two patients, no SNs were visualized on scintigraphy. In the remaining 25 patients, a median (range) of 3 (1–4) SNs per patient were removed. Two patients showed no malignancy on histopathological examination of the testis. Of the 23 patients diagnosed with TGCT (16 seminomas, seven non‐seminomas), three (13.0%) had occult metastatic disease. All 23 patients were without evidence of disease at a median (range) follow‐up of 63.9 (29.0–143.4) months. CONCLUSION: The SN procedure allows early identification of patients with occult metastatic disease in clinical stage I TGCT, enabling early treatment. John Wiley and Sons Inc. 2019-03-28 2019-09 /pmc/articles/PMC6850062/ /pubmed/30417511 http://dx.doi.org/10.1111/bju.14618 Text en © 2018 The Authors BJU International Published by John Wiley & Sons Ltd on behalf of BJU International This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Urological Oncology Blok, Joost M. Kerst, J. Martijn Vegt, Erik Brouwer, Oscar R. Meijer, Richard P. Bosch, J.L.H. Ruud Bex, Axel van der Poel, Henk G. Horenblas, Simon Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease |
title | Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease |
title_full | Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease |
title_fullStr | Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease |
title_full_unstemmed | Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease |
title_short | Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease |
title_sort | sentinel node biopsy in clinical stage i testicular cancer enables early detection of occult metastatic disease |
topic | Urological Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850062/ https://www.ncbi.nlm.nih.gov/pubmed/30417511 http://dx.doi.org/10.1111/bju.14618 |
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