Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens?

AIMS: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens. METHODS AND RESULTS: Using the Dutch pathology registry (PALGA), surgi...

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Detalles Bibliográficos
Autores principales: Derks, Jules L, Dingemans, Anne‐Marie C, van Suylen, Robert‐Jan, den Bakker, Michael A, Damhuis, Ronald A M, van den Broek, Esther C, Speel, Ernst‐Jan, Thunnissen, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850184/
https://www.ncbi.nlm.nih.gov/pubmed/30485478
http://dx.doi.org/10.1111/his.13800

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