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TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS

Impaired classical NF‐κB pathway signaling causes reduced antibody responses to T‐independent (TI) antigens. We investigated the potential reasons for defective TI responses in mice lacking the atypical inhibitory kappa B (IκB) protein of the NF‐κB pathway, IκBNS. Analyses of the plasma cell compart...

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Detalles Bibliográficos
Autores principales: Khoenkhoen, Sharesta, Erikson, Elina, Ádori, Monika, Stark, Julian M, Scholz, Jean L, Cancro, Michael P, Pedersen, Gabriel K, Karlsson Hedestam, Gunilla B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850186/
https://www.ncbi.nlm.nih.gov/pubmed/30597621
http://dx.doi.org/10.1111/imcb.12228