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Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series

Mycobacterium haemophilum is an uncommonly encountered acid-fast staining bacillus (AFB) that can cause a broad range of infections. We describe a tertiary care center's experience with M. haemophilum infections identified from 2000 to 2015. Ten adult patients were identified with M. haemophilu...

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Detalles Bibliográficos
Autores principales: Tyner, Harmony L., Wilson, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850245/
https://www.ncbi.nlm.nih.gov/pubmed/31723708
http://dx.doi.org/10.1016/j.jctube.2017.06.002
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author Tyner, Harmony L.
Wilson, John W.
author_facet Tyner, Harmony L.
Wilson, John W.
author_sort Tyner, Harmony L.
collection PubMed
description Mycobacterium haemophilum is an uncommonly encountered acid-fast staining bacillus (AFB) that can cause a broad range of infections. We describe a tertiary care center's experience with M. haemophilum infections identified from 2000 to 2015. Ten adult patients were identified with M. haemophilum infections, and most had immunocompromising conditions. M. haemophilum presented in one of two syndromes: a peripheral cutaneous infection presenting with skin nodularity and local invasion, and a cervicofacial infection involving regional lymph nodes. Duration of therapy was variable (0–18 months) and was dependent on the underlying syndrome and immunological status of the patient. Treatment responses were favorable in all patients. During therapy, three patients developed culture-negative aseptic cutaneous lesions, consistent with immunologic reconstitution inflammatory syndrome (IRIS); we postulate that such reactions may not be uncommon with select M. haemophilum infections.
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spelling pubmed-68502452019-11-13 Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series Tyner, Harmony L. Wilson, John W. J Clin Tuberc Other Mycobact Dis Article Mycobacterium haemophilum is an uncommonly encountered acid-fast staining bacillus (AFB) that can cause a broad range of infections. We describe a tertiary care center's experience with M. haemophilum infections identified from 2000 to 2015. Ten adult patients were identified with M. haemophilum infections, and most had immunocompromising conditions. M. haemophilum presented in one of two syndromes: a peripheral cutaneous infection presenting with skin nodularity and local invasion, and a cervicofacial infection involving regional lymph nodes. Duration of therapy was variable (0–18 months) and was dependent on the underlying syndrome and immunological status of the patient. Treatment responses were favorable in all patients. During therapy, three patients developed culture-negative aseptic cutaneous lesions, consistent with immunologic reconstitution inflammatory syndrome (IRIS); we postulate that such reactions may not be uncommon with select M. haemophilum infections. Elsevier 2017-06-28 /pmc/articles/PMC6850245/ /pubmed/31723708 http://dx.doi.org/10.1016/j.jctube.2017.06.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Tyner, Harmony L.
Wilson, John W.
Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series
title Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series
title_full Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series
title_fullStr Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series
title_full_unstemmed Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series
title_short Fifteen-year clinical experience with Mycobacterium haemophilum at the Mayo Clinic: A case series
title_sort fifteen-year clinical experience with mycobacterium haemophilum at the mayo clinic: a case series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850245/
https://www.ncbi.nlm.nih.gov/pubmed/31723708
http://dx.doi.org/10.1016/j.jctube.2017.06.002
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