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The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer
The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate (DS) generates biological information that can be unique to each of these glycosaminoglycans (GAGs), and changes in their composition are translated into alterations in the binding profiles of these molecules. C...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850286/ https://www.ncbi.nlm.nih.gov/pubmed/30637950 http://dx.doi.org/10.1111/febs.14748 |
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author | Pudełko, Adam Wisowski, Grzegorz Olczyk, Krystyna Koźma, Ewa Maria |
author_facet | Pudełko, Adam Wisowski, Grzegorz Olczyk, Krystyna Koźma, Ewa Maria |
author_sort | Pudełko, Adam |
collection | PubMed |
description | The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate (DS) generates biological information that can be unique to each of these glycosaminoglycans (GAGs), and changes in their composition are translated into alterations in the binding profiles of these molecules. CS/DS can bind to various cytokines and growth factors, cell surface receptors, adhesion molecules, enzymes and fibrillar glycoproteins of the extracellular matrix, thereby influencing both cell behavior and the biomechanical and biochemical properties of the matrix. In this review, we summarize the current knowledge concerning CS/DS metabolism in the human cancer stroma. The remodeling of the GAG profile in the tumor niche is manifested as a substantial increase in the CS content and a gradual decrease in the proportion between DS and CS. Furthermore, the composition of CS and DS is also affected, which results in a substantial increase in the 6‐O‐sulfated and/or unsulfated disaccharide content, which is concomitant with a decrease in the 4‐O‐sulfation level. Here, we discuss the possible impact of alterations in the CS/DS sulfation pattern on the binding capacity and specificity of these GAGs. Moreover, we propose potential consequences of the stromal accumulation of chondroitin‐6‐sulfate for the progression and metastasis of cancer. |
format | Online Article Text |
id | pubmed-6850286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68502862019-11-18 The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer Pudełko, Adam Wisowski, Grzegorz Olczyk, Krystyna Koźma, Ewa Maria FEBS J Review Article The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate (DS) generates biological information that can be unique to each of these glycosaminoglycans (GAGs), and changes in their composition are translated into alterations in the binding profiles of these molecules. CS/DS can bind to various cytokines and growth factors, cell surface receptors, adhesion molecules, enzymes and fibrillar glycoproteins of the extracellular matrix, thereby influencing both cell behavior and the biomechanical and biochemical properties of the matrix. In this review, we summarize the current knowledge concerning CS/DS metabolism in the human cancer stroma. The remodeling of the GAG profile in the tumor niche is manifested as a substantial increase in the CS content and a gradual decrease in the proportion between DS and CS. Furthermore, the composition of CS and DS is also affected, which results in a substantial increase in the 6‐O‐sulfated and/or unsulfated disaccharide content, which is concomitant with a decrease in the 4‐O‐sulfation level. Here, we discuss the possible impact of alterations in the CS/DS sulfation pattern on the binding capacity and specificity of these GAGs. Moreover, we propose potential consequences of the stromal accumulation of chondroitin‐6‐sulfate for the progression and metastasis of cancer. John Wiley and Sons Inc. 2019-02-05 2019-05 /pmc/articles/PMC6850286/ /pubmed/30637950 http://dx.doi.org/10.1111/febs.14748 Text en © 2019 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pudełko, Adam Wisowski, Grzegorz Olczyk, Krystyna Koźma, Ewa Maria The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer |
title | The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer |
title_full | The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer |
title_fullStr | The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer |
title_full_unstemmed | The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer |
title_short | The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer |
title_sort | dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850286/ https://www.ncbi.nlm.nih.gov/pubmed/30637950 http://dx.doi.org/10.1111/febs.14748 |
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