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Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice

OBJECTIVES: To assess the protective effects of a 0.454% stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10‐day in situ model. METHODS: This was a double‐blind, randomized, 2‐treatment, 4‐period, crossover in situ trial involving healthy adult...

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Autores principales: West, Nicola X., He, Tao, Hellin, Nikki, Claydon, Nicholas, Seong, Joon, Macdonald, Emma, Farrell, Svetlana, Eusebio, Rachelle, Wilberg, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850309/
https://www.ncbi.nlm.nih.gov/pubmed/30556372
http://dx.doi.org/10.1111/idh.12379
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author West, Nicola X.
He, Tao
Hellin, Nikki
Claydon, Nicholas
Seong, Joon
Macdonald, Emma
Farrell, Svetlana
Eusebio, Rachelle
Wilberg, Aneta
author_facet West, Nicola X.
He, Tao
Hellin, Nikki
Claydon, Nicholas
Seong, Joon
Macdonald, Emma
Farrell, Svetlana
Eusebio, Rachelle
Wilberg, Aneta
author_sort West, Nicola X.
collection PubMed
description OBJECTIVES: To assess the protective effects of a 0.454% stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10‐day in situ model. METHODS: This was a double‐blind, randomized, 2‐treatment, 4‐period, crossover in situ trial involving healthy adult participants. Participants were randomized to a treatment sequence involving the following products: a highly bioavailable 0.454% stannous fluoride dentifrice (Procter & Gamble) and a marketed dentifrice control containing 0.24% sodium fluoride and 0.3% triclosan (Colgate‐Palmolive). Each study period took place over 10 days. Participants wore an intra‐oral appliance retaining two polished human enamel samples for 6 hours per day. Two times per day they swished with the assigned dentifrice slurry and four times per day they swished with 250 mL of orange juice (25 mL per minute) over a 10‐minute period. Contact profilometry measurements were made for each sample at baseline and day 10 to determine surface change. RESULTS: Thirty‐six participants were enrolled and 33 completed the study (mean age = 40.5 years). The stannous fluoride dentifrice demonstrated 93.5% less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.097 µm and 1.495 µm, respectively. Both products were well tolerated. CONCLUSION: The stannous fluoride dentifrice demonstrated significantly greater erosion protection efficacy relative to the NaF/triclosan dentifrice in this randomized in situ clinical trial.
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spelling pubmed-68503092019-11-18 Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice West, Nicola X. He, Tao Hellin, Nikki Claydon, Nicholas Seong, Joon Macdonald, Emma Farrell, Svetlana Eusebio, Rachelle Wilberg, Aneta Int J Dent Hyg Original Articles OBJECTIVES: To assess the protective effects of a 0.454% stabilized stannous fluoride dentifrice and a marketed triclosan dentifrice against enamel erosion in a 10‐day in situ model. METHODS: This was a double‐blind, randomized, 2‐treatment, 4‐period, crossover in situ trial involving healthy adult participants. Participants were randomized to a treatment sequence involving the following products: a highly bioavailable 0.454% stannous fluoride dentifrice (Procter & Gamble) and a marketed dentifrice control containing 0.24% sodium fluoride and 0.3% triclosan (Colgate‐Palmolive). Each study period took place over 10 days. Participants wore an intra‐oral appliance retaining two polished human enamel samples for 6 hours per day. Two times per day they swished with the assigned dentifrice slurry and four times per day they swished with 250 mL of orange juice (25 mL per minute) over a 10‐minute period. Contact profilometry measurements were made for each sample at baseline and day 10 to determine surface change. RESULTS: Thirty‐six participants were enrolled and 33 completed the study (mean age = 40.5 years). The stannous fluoride dentifrice demonstrated 93.5% less enamel loss than the NaF/triclosan dentifrice (P < 0.001) at Day 10, with median enamel loss of 0.097 µm and 1.495 µm, respectively. Both products were well tolerated. CONCLUSION: The stannous fluoride dentifrice demonstrated significantly greater erosion protection efficacy relative to the NaF/triclosan dentifrice in this randomized in situ clinical trial. John Wiley and Sons Inc. 2019-02-19 2019-08 /pmc/articles/PMC6850309/ /pubmed/30556372 http://dx.doi.org/10.1111/idh.12379 Text en © 2018 The Authors. International Journal of Dental Hygiene Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
West, Nicola X.
He, Tao
Hellin, Nikki
Claydon, Nicholas
Seong, Joon
Macdonald, Emma
Farrell, Svetlana
Eusebio, Rachelle
Wilberg, Aneta
Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice
title Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice
title_full Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice
title_fullStr Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice
title_full_unstemmed Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice
title_short Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice
title_sort randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850309/
https://www.ncbi.nlm.nih.gov/pubmed/30556372
http://dx.doi.org/10.1111/idh.12379
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