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Temperature‐dependent irreversible conformational change of recombinant ADAMTS13 upon metal ion chelation

BACKGROUND: The catalytic domain of ADAMTS13 possesses one Zn(2+) and up to three putative Ca(2+) binding sites and can be inactivated by chelating agents. Although replenishment with an appropriate metallic cation is thought to restore the enzyme's proteolytic activity fully, ADAMTS13 stabilit...

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Detalles Bibliográficos
Autores principales:	Rottensteiner, Hanspeter, Kaufmann, Stefan, Rathgeb, Anna, Kink, Barbara, Plaimauer, Barbara, Matthiessen, Peter, Hann, Stephan, Scheiflinger, Friedrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	HAEMOSTASIS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850365/ https://www.ncbi.nlm.nih.gov/pubmed/31006963 http://dx.doi.org/10.1111/jth.14440

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