Cargando…

In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling

Glucocerebrosidase (GBA) is a lysosomal β‐glucosidase‐degrading glucosylceramide. Its deficiency causes Gaucher disease (GD), a common lysosomal storage disorder. Carrying a genetic abnormality in GBA constitutes at present the largest genetic risk factor for Parkinson's disease (PD). Condurito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuo, Chi‐Lin, Kallemeijn, Wouter W., Lelieveld, Lindsey T., Mirzaian, Mina, Zoutendijk, Iris, Vardi, Ayelet, Futerman, Anthony H., Meijer, Annemarie H., Spaink, Herman P., Overkleeft, Herman S., Aerts, Johannes M.F.G., Artola, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850446/ https://www.ncbi.nlm.nih.gov/pubmed/30600575 http://dx.doi.org/10.1111/febs.14744

Ejemplares similares

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor
por: Artola, Marta, et al.
Publicado: (2017)

Xylose‐Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase
por: Su, Qin, et al.
Publicado: (2021)

Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics
por: Kytidou, Kassiani, et al.
Publicado: (2020)

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish
por: Artola, Marta, et al.
Publicado: (2019)

Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors
por: Beenakker, Thomas J. M., et al.
Publicado: (2017)

1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease
por: Kok, Ken, et al.
Publicado: (2022)

An Orthogonally Protected Cyclitol for the Construction of Nigerose- and Dextran-Mimetic Cyclophellitols
por: Ofman, Tim P., et al.
Publicado: (2021)

An Epoxide Intermediate in Glycosidase Catalysis
por: Sobala, Lukasz F., et al.
Publicado: (2020)

Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases
por: de Boer, Casper, et al.
Publicado: (2020)

Correction: Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases
por: de Boer, Casper, et al.
Publicado: (2021)

General Method for the Synthesis of (−)-Conduritol C and Analogs from Chiral Cyclohexadienediol Scaffolds
por: Tibhe, Gaurao D., et al.
Publicado: (2018)

Direct Stereoselective Aziridination of Cyclohexenols with 3‐Amino‐2‐(trifluoromethyl)quinazolin‐4(3H)‐one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors
por: Artola, Marta, et al.
Publicado: (2019)

Host-Pathogen Interactions Made Transparent with the Zebrafish Model
por: Meijer, Annemarie H, et al.
Publicado: (2011)

Dynamics of Ligand Binding to a Rigid Glycosidase
por: Ben Bdira, Fredj, et al.
Publicado: (2020)

Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.
por: Lelieveld, Lindsey T., et al.
Publicado: (2022)

Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish
por: van der Vaart, Michiel, et al.
Publicado: (2012)

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model
por: Torraca, Vincenzo, et al.
Publicado: (2014)

Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish
por: Yang, Shuxin, et al.
Publicado: (2015)

Synthesis of Cyclophellitol Utilizing a Palladium Chloride Mediated-Ferrier-II Rearrangement
por: Takahashi, Hideyo, et al.
Publicado: (2005)

Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways
por: Vardi, Ayelet, et al.
Publicado: (2021)

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease
por: Kytidou, Kassiani, et al.
Publicado: (2017)

Rapid screening of innate immune gene expression in zebrafish using reverse transcription - multiplex ligation-dependent probe amplification
por: Rotman, Janneke, et al.
Publicado: (2011)

A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery
por: Veneman, Wouter J, et al.
Publicado: (2013)

Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients
por: Smid, Bouwien E., et al.
Publicado: (2016)

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system
por: van der Vaart, Michiel, et al.
Publicado: (2013)

Consequences of a global enzyme shortage of agalsidase beta in adult Dutch Fabry patients
por: Smid, Bouwien E, et al.
Publicado: (2011)

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
por: Veneman, Wouter J., et al.
Publicado: (2014)

Lipid-mimicking phosphorus-based glycosidase inactivators as pharmacological chaperones for the treatment of Gaucher's disease
por: Scherer, Manuel, et al.
Publicado: (2021)

Alkaloid Glycosidase Inhibitors
por: Elbein, Alan D., et al.
Publicado: (1999)

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis
por: Gaspar, Paulo, et al.
Publicado: (2014)

Correlative light and electron microscopy imaging of autophagy in a zebrafish infection model
por: Hosseini, Rohola, et al.
Publicado: (2014)

MicroRNA-146 function in the innate immune transcriptome response of zebrafish embryos to Salmonella typhimurium infection
por: Ordas, Anita, et al.
Publicado: (2013)

Analysis of RNAseq datasets from a comparative infectious disease zebrafish model using GeneTiles bioinformatics
por: Veneman, Wouter J., et al.
Publicado: (2014)

Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease
por: Vardi, Ayelet, et al.
Publicado: (2020)

Parallel deep transcriptome and proteome analysis of zebrafish larvae
por: Palmblad, Magnus, et al.
Publicado: (2013)

Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection
por: Hu, Wanbin, et al.
Publicado: (2019)

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions
por: Boer, Daphne E., et al.
Publicado: (2021)

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes
por: Kallemeijn, Wouter W., et al.
Publicado: (2017)

Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda
por: van Soest, Joost J, et al.
Publicado: (2011)

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
por: Benard, Erica L., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_03ervs8faaq97j3tgdd38je44v