SNARE proteins rescue impaired autophagic flux in Down syndrome

Down syndrome (DS) is a chromosomal disorder caused by trisomy of chromosome 21 (Ts21). Unbalanced karyotypes can lead to dysfunction of the proteostasis network (PN) and disrupted proteostasis is mechanistically associated with multiple DS comorbidities. Autophagy is a critical component of the PN...

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Detalles Bibliográficos
Autores principales: Aivazidis, Stefanos, Jain, Abhilasha, Rauniyar, Abhishek K., Anderson, Colin C., Marentette, John O., Orlicky, David J., Fritz, Kristofer S., Harris, Peter S., Siegel, David, Maclean, Kenneth N., Roede, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850524/
https://www.ncbi.nlm.nih.gov/pubmed/31714914
http://dx.doi.org/10.1371/journal.pone.0223254

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