Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night ca...

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Detalles Bibliográficos
Autores principales: Haraguchi, Shogo, Kamata, Masaki, Tokita, Takuma, Tashiro, Kei-ichiro, Sato, Miku, Nozaki, Mitsuki, Okamoto-Katsuyama, Mayumi, Shimizu, Isao, Han, Guofeng, Chowdhury, Vishwajit Sur, Lei, Xiao-Feng, Miyazaki, Takuro, Kim-Kaneyama, Joo-ri, Nakamachi, Tomoya, Matsuda, Kouhei, Ohtaki, Hirokazu, Tokumoto, Toshinobu, Tachibana, Tetsuya, Miyazaki, Akira, Tsutsui, Kazuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850767/
https://www.ncbi.nlm.nih.gov/pubmed/31566568
http://dx.doi.org/10.7554/eLife.45306

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