DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging

Genome instability is a hallmark of aging and contributes to age-related disorders such as cancer and Alzheimer’s disease. The accumulation of DNA damage during aging has been linked to altered cell cycle dynamics and the failure of cell cycle checkpoints. Here, we use single cell imaging to study t...

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Detalles Bibliográficos
Autores principales: Crane, Matthew M, Russell, Adam E, Schafer, Brent J, Blue, Ben W, Whalen, Riley, Almazan, Jared, Hong, Mung Gi, Nguyen, Bao, Goings, Joslyn E, Chen, Kenneth L, Kelly, Ryan, Kaeberlein, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850777/
https://www.ncbi.nlm.nih.gov/pubmed/31714209
http://dx.doi.org/10.7554/eLife.50778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850777/
https://www.ncbi.nlm.nih.gov/pubmed/31714209
http://dx.doi.org/10.7554/eLife.50778

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