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Unexpected encounter of the parasitic kind
Both parasitology and stem cell research are important disciplines in their own right. Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality globally. Stem cell research, on the other hand, focuses on the potential for r...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851008/ https://www.ncbi.nlm.nih.gov/pubmed/31768219 http://dx.doi.org/10.4252/wjsc.v11.i11.904 |
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author | Matthews, Holly Noulin, Florian |
author_facet | Matthews, Holly Noulin, Florian |
author_sort | Matthews, Holly |
collection | PubMed |
description | Both parasitology and stem cell research are important disciplines in their own right. Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality globally. Stem cell research, on the other hand, focuses on the potential for regenerative medicine for a range of diseases including cancer and regenerative therapies. Though these two topics might appear distant, there are some “unexpected encounters”. In this review, we summarise the various links between parasites and stem cells. First, we discuss how parasites’ own stem cells represent interesting models of regeneration that can be translated to human stem cell regeneration. Second, we explore the interactions between parasites and host stem cells during the course of infection. Third, we investigate from a clinical perspective, how stem cell regeneration can be exploited to help circumvent the damage induced by parasitic infection and its potential to serve as treatment options for parasitic diseases in the future. Finally, we discuss the importance of screening for pathogens during organ transplantation by presenting some clinical cases of parasitic infection following stem cell therapy. |
format | Online Article Text |
id | pubmed-6851008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-68510082019-11-26 Unexpected encounter of the parasitic kind Matthews, Holly Noulin, Florian World J Stem Cells Review Both parasitology and stem cell research are important disciplines in their own right. Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality globally. Stem cell research, on the other hand, focuses on the potential for regenerative medicine for a range of diseases including cancer and regenerative therapies. Though these two topics might appear distant, there are some “unexpected encounters”. In this review, we summarise the various links between parasites and stem cells. First, we discuss how parasites’ own stem cells represent interesting models of regeneration that can be translated to human stem cell regeneration. Second, we explore the interactions between parasites and host stem cells during the course of infection. Third, we investigate from a clinical perspective, how stem cell regeneration can be exploited to help circumvent the damage induced by parasitic infection and its potential to serve as treatment options for parasitic diseases in the future. Finally, we discuss the importance of screening for pathogens during organ transplantation by presenting some clinical cases of parasitic infection following stem cell therapy. Baishideng Publishing Group Inc 2019-11-26 2019-11-26 /pmc/articles/PMC6851008/ /pubmed/31768219 http://dx.doi.org/10.4252/wjsc.v11.i11.904 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Matthews, Holly Noulin, Florian Unexpected encounter of the parasitic kind |
title | Unexpected encounter of the parasitic kind |
title_full | Unexpected encounter of the parasitic kind |
title_fullStr | Unexpected encounter of the parasitic kind |
title_full_unstemmed | Unexpected encounter of the parasitic kind |
title_short | Unexpected encounter of the parasitic kind |
title_sort | unexpected encounter of the parasitic kind |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851008/ https://www.ncbi.nlm.nih.gov/pubmed/31768219 http://dx.doi.org/10.4252/wjsc.v11.i11.904 |
work_keys_str_mv | AT matthewsholly unexpectedencounteroftheparasitickind AT noulinflorian unexpectedencounteroftheparasitickind |