Cargando…

Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells

Previous work has shown that reduced expression of PLCXD3, a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin secretion with an unclear mechanism. In the current study, we aim to investigate the mechanism underlying this effect using human islets and rat INS-1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aljaibeji, Hayat, Mukhopadhyay, Debasmita, Mohammed, Abdul Khader, Dhaiban, Sarah, Hachim, Mahmood Y., Elemam, Noha M., Sulaiman, Nabil, Salehi, Albert, Taneera, Jalal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851018/ https://www.ncbi.nlm.nih.gov/pubmed/31781030 http://dx.doi.org/10.3389/fendo.2019.00735

Ejemplares similares

Genetic Variants of the PLCXD3 Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population
por: Aljaibeji, Hayat, et al.
Publicado: (2020)

An Integrative Phenotype–Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a Candidate Gene for Obesity and Type 2 Diabetes
por: Hachim, Mahmood Y., et al.
Publicado: (2020)

Profiling Levels of Serum microRNAs and Soluble ACE2 in COVID-19 Patients
por: Elemam, Noha Mousaad, et al.
Publicado: (2022)

Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients
por: Elemam, Noha Mousaad, et al.
Publicado: (2021)

EXOC6 (Exocyst Complex Component 6) Is Associated with the Risk of Type 2 Diabetes and Pancreatic β-Cell Dysfunction
por: Sulaiman, Nabil, et al.
Publicado: (2022)

Prediabetes and diabetes prevalence and risk factors comparison between ethnic groups in the United Arab Emirates
por: Hamoudi, Rifat, et al.
Publicado: (2019)

Vitamin A levels are decreased but not influenced by glucose- or lipid-lowering medications in subjects with type 2 diabetes
por: Taneera, Jalal, et al.
Publicado: (2021)

Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors
por: Taneera, Jalal, et al.
Publicado: (2020)

Toxicogenomic analysis of publicly available transcriptomic data can predict food, drugs, and chemical-induced asthma
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2019)

The Beneficial and Debilitating Effects of Environmental and Microbial Toxins, Drugs, Organic Solvents and Heavy Metals on the Onset and Progression of Multiple Sclerosis
por: Hachim, Mahmood Y., et al.
Publicado: (2019)

Targeting Chemokines and Chemokine Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
por: Dhaiban, Sarah, et al.
Publicado: (2020)

Differentially Expressed Genes of Natural Killer Cells Can Distinguish Rheumatoid Arthritis Patients from Healthy Controls
por: Elemam, Noha Mousaad, et al.
Publicado: (2020)

The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapy
por: Mahgoub, Eglal, et al.
Publicado: (2022)

Splice site SNPs of phospholipase PLCXD3 are significantly associated with variant and sporadic Creutzfeldt-Jakob disease
por: Bishop, Matthew T, et al.
Publicado: (2013)

Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study
por: Balendra, Rubika, et al.
Publicado: (2016)

Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell Physiology
por: Khalique, Anila, et al.
Publicado: (2022)

Expression Silencing of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 Conferred Its Role in Pancreatic β-Cell Physiology and Insulin Secretion
por: Saeed, Rania, et al.
Publicado: (2023)

The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
por: Del Signore, Steven J., et al.
Publicado: (2019)

Understanding the Role of Innate Immune Cells and Identifying Genes in Breast Cancer Microenvironment
por: Shihab, Israa, et al.
Publicado: (2020)

Copine 3 “CPNE3” is a novel regulator for insulin secretion and glucose uptake in pancreatic β-cells
por: El-Huneidi, Waseem, et al.
Publicado: (2021)

Clinical and Laboratory Profile of Hospitalized Symptomatic COVID-19 Patients: Case Series Study From the First COVID-19 Center in the UAE
por: Hannawi, Suad, et al.
Publicado: (2021)

FRI141 Dietary Salt Regulates mTORC1 Signaling In Humans And Mice With Hypertension
por: Aljaibeji, Hayat, et al.
Publicado: (2023)

Rituximab Prevents the Development of Experimental Autoimmune Encephalomyelitis (EAE): Comparison with Prophylactic, Therapeutic or Combinational Regimens
por: Al-ani, Mena R, et al.
Publicado: (2020)

Molecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment
por: Al-Ani, Mena, et al.
Publicado: (2021)

A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion
por: Jonsson, Anna, et al.
Publicado: (2009)

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer
por: Bhattacharya, Debasmita, et al.
Publicado: (2019)

Confounding Patient Factors Affecting the Proper Interpretation of the Periostin Level as a Biomarker in Asthma Development
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2020)

Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2021)

Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling
por: Elemam, Noha M., et al.
Publicado: (2022)

Author Correction: Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2021)

Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2021)

Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2020)

Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic β-Cell Function
por: Saeed, Rania, et al.
Publicado: (2023)

Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression
por: Li, Zhiming, et al.
Publicado: (2016)

Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro
por: Root-Bernstein, Robert, et al.
Publicado: (2014)

Editorial: Endocrine Disrupters and Metabolism
por: Gibert, Yann, et al.
Publicado: (2019)

Disruption in Thyroid Signaling Pathway: A Mechanism for the Effect of Endocrine-Disrupting Chemicals on Child Neurodevelopment
por: Ghassabian, Akhgar, et al.
Publicado: (2018)

Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study
por: Butler, Alexandra E., et al.
Publicado: (2020)

Hypoxia Signaling and Circadian Disruption in and by Pheochromocytoma
por: Tabebi, Mouna, et al.
Publicado: (2018)

Antidepressants as Endocrine Disrupting Compounds in Fish
por: Thompson, William Andrew, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_66kl2ld087a01ibg5slpk85ii0