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HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review
OBJECTIVES: We sought to estimate the prevalence of HIV drug resistance and describe the common HIV genetic mutations in patients failing antiretroviral therapy (ART). We also investigated the impact of HIV resistance tests results on patients’ management. METHODS: We conducted a retrospective recor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
OMJ
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851064/ https://www.ncbi.nlm.nih.gov/pubmed/31745412 http://dx.doi.org/10.5001/omj.2019.91 |
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author | Al-Omairi, Omaira Elgalib, Ali Al Kindi, Hanan |
author_facet | Al-Omairi, Omaira Elgalib, Ali Al Kindi, Hanan |
author_sort | Al-Omairi, Omaira |
collection | PubMed |
description | OBJECTIVES: We sought to estimate the prevalence of HIV drug resistance and describe the common HIV genetic mutations in patients failing antiretroviral therapy (ART). We also investigated the impact of HIV resistance tests results on patients’ management. METHODS: We conducted a retrospective record review for all HIV genotypic resistance tests requested at the HIV clinic of a tertiary HIV center in Muscat, Oman, from April 2011 to May 2017. RESULTS: A total of 98 genotypic resistance tests for 84 patients failing ART were analyzed; 82 tests for 69 patients (83.7%, 95% confidence interval: 76.4–91.0) showed resistance to at least one ART drug. M184V/I, K103N/S, and G190A/S/E were the most common mutations detected. Among the tests with a resistant virus, 78.0% were followed by switching ART based on the resistance test profile resulting in virus load suppression after six months in 60.9% of the cases. CONCLUSIONS: HIV drug resistance is very common among HIV patients failing ART in Oman, and should be considered in those patients. Switching ART treatment based on the resistance test result leads to a good virological response in adherent patients. |
format | Online Article Text |
id | pubmed-6851064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | OMJ |
record_format | MEDLINE/PubMed |
spelling | pubmed-68510642019-11-19 HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review Al-Omairi, Omaira Elgalib, Ali Al Kindi, Hanan Oman Med J Original Article OBJECTIVES: We sought to estimate the prevalence of HIV drug resistance and describe the common HIV genetic mutations in patients failing antiretroviral therapy (ART). We also investigated the impact of HIV resistance tests results on patients’ management. METHODS: We conducted a retrospective record review for all HIV genotypic resistance tests requested at the HIV clinic of a tertiary HIV center in Muscat, Oman, from April 2011 to May 2017. RESULTS: A total of 98 genotypic resistance tests for 84 patients failing ART were analyzed; 82 tests for 69 patients (83.7%, 95% confidence interval: 76.4–91.0) showed resistance to at least one ART drug. M184V/I, K103N/S, and G190A/S/E were the most common mutations detected. Among the tests with a resistant virus, 78.0% were followed by switching ART based on the resistance test profile resulting in virus load suppression after six months in 60.9% of the cases. CONCLUSIONS: HIV drug resistance is very common among HIV patients failing ART in Oman, and should be considered in those patients. Switching ART treatment based on the resistance test result leads to a good virological response in adherent patients. OMJ 2019-11 /pmc/articles/PMC6851064/ /pubmed/31745412 http://dx.doi.org/10.5001/omj.2019.91 Text en The OMJ is Published Bimonthly and Copyrighted 2019 by the OMSB. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License. http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Original Article Al-Omairi, Omaira Elgalib, Ali Al Kindi, Hanan HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review |
title | HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review |
title_full | HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review |
title_fullStr | HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review |
title_full_unstemmed | HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review |
title_short | HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review |
title_sort | hiv drug resistance among patients failing therapy at a tertiary center in oman: a case record review |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851064/ https://www.ncbi.nlm.nih.gov/pubmed/31745412 http://dx.doi.org/10.5001/omj.2019.91 |
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