KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia

We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment...

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Detalles Bibliográficos
Autores principales: Saad, Ashraf Abdullah, Beshlawi, Ismail, Zachariah, Mathew, Wali, Yasser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OMJ 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851066/
https://www.ncbi.nlm.nih.gov/pubmed/31745420
http://dx.doi.org/10.5001/omj.2019.99
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author Saad, Ashraf Abdullah
Beshlawi, Ismail
Zachariah, Mathew
Wali, Yasser
author_facet Saad, Ashraf Abdullah
Beshlawi, Ismail
Zachariah, Mathew
Wali, Yasser
author_sort Saad, Ashraf Abdullah
collection PubMed
description We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment for AML in our 14-month-old patient. This article aims to scrutinize the catastrophic sequel of such an overlap in leukemia and refutes the contemporary diagnostic methods.
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spelling pubmed-68510662019-11-19 KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia Saad, Ashraf Abdullah Beshlawi, Ismail Zachariah, Mathew Wali, Yasser Oman Med J Case Report We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment for AML in our 14-month-old patient. This article aims to scrutinize the catastrophic sequel of such an overlap in leukemia and refutes the contemporary diagnostic methods. OMJ 2019-11 /pmc/articles/PMC6851066/ /pubmed/31745420 http://dx.doi.org/10.5001/omj.2019.99 Text en The OMJ is Published Bimonthly and Copyrighted 2019 by the OMSB. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License. http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Case Report
Saad, Ashraf Abdullah
Beshlawi, Ismail
Zachariah, Mathew
Wali, Yasser
KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia
title KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia
title_full KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia
title_fullStr KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia
title_full_unstemmed KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia
title_short KMT2A-MLLT3 AML Masquerading as JMML may Disguise Fatal Leukemia
title_sort kmt2a-mllt3 aml masquerading as jmml may disguise fatal leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851066/
https://www.ncbi.nlm.nih.gov/pubmed/31745420
http://dx.doi.org/10.5001/omj.2019.99
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