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Characterization of the dynamics and the conformational entropy in the binding between TAZ1 and CTAD-HIF-1α
The interaction between the C-terminal transactivation domain of HIF-1α (CTAD-HIF-1α) and the transcriptional adapter zinc binding 1 (TAZ1) domain of CREB binding protein participate in the initiation of gene transcription during hypoxia. Unbound CTAD-HIF-1α is disordered but undergoes a disorder-to...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851107/ https://www.ncbi.nlm.nih.gov/pubmed/31719609 http://dx.doi.org/10.1038/s41598-019-53067-8 |