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Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin
Grapefruit juice (GFJ) and naringin when consumed previously or together with medications may alter their bioavailavility and consequently the clinical effect. Ifosfamide (IF) is an antitumoral agent prescribed against various types of cancer. Nevertheless, there is no information regarding its inte...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851181/ https://www.ncbi.nlm.nih.gov/pubmed/31719649 http://dx.doi.org/10.1038/s41598-019-53204-3 |
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author | Madrigal-Bujaidar, Eduardo Pérez-Montoya, Edilberto García-Medina, Sandra Cristóbal-Luna, José Melesio Morales-González, José A. Madrigal-Santillán, Eduardo Osiris Paniagua-Pérez, Rogelio Álvarez-González, Isela |
author_facet | Madrigal-Bujaidar, Eduardo Pérez-Montoya, Edilberto García-Medina, Sandra Cristóbal-Luna, José Melesio Morales-González, José A. Madrigal-Santillán, Eduardo Osiris Paniagua-Pérez, Rogelio Álvarez-González, Isela |
author_sort | Madrigal-Bujaidar, Eduardo |
collection | PubMed |
description | Grapefruit juice (GFJ) and naringin when consumed previously or together with medications may alter their bioavailavility and consequently the clinical effect. Ifosfamide (IF) is an antitumoral agent prescribed against various types of cancer. Nevertheless, there is no information regarding its interaction with the ingestion of GFJ or naringin. The aims of the present report were validating a method for the quantitation of IF in the plasma of mouse, and determine if mice pretreated with GFJ or naringin may modify the IF pharmacokinetics. Our HPLC results to quantify IF showed adequate intra and inter-day precision (RSD < 15%) and accuracy (RE < 15%) indicating reliability. Also, the administration of GFJ or naringin increased C(max) of IF 22.9% and 17.8%, respectively, and decreased T(max) of IF 19.2 and 53.8%, respectively. The concentration of IF was higher when GFJ (71.35 ± 3.5 µg/mL) was administered with respect to that obtained in the combination naringin with IF (64.12 ± µg/mL); however, the time required to reach such concentration was significantly lower when naringin was administered (p < 0.5). We concluded that pre-administering GFJ and naringin to mice increased the T(max) and decreased the C(max) of IF. |
format | Online Article Text |
id | pubmed-6851181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68511812019-11-19 Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin Madrigal-Bujaidar, Eduardo Pérez-Montoya, Edilberto García-Medina, Sandra Cristóbal-Luna, José Melesio Morales-González, José A. Madrigal-Santillán, Eduardo Osiris Paniagua-Pérez, Rogelio Álvarez-González, Isela Sci Rep Article Grapefruit juice (GFJ) and naringin when consumed previously or together with medications may alter their bioavailavility and consequently the clinical effect. Ifosfamide (IF) is an antitumoral agent prescribed against various types of cancer. Nevertheless, there is no information regarding its interaction with the ingestion of GFJ or naringin. The aims of the present report were validating a method for the quantitation of IF in the plasma of mouse, and determine if mice pretreated with GFJ or naringin may modify the IF pharmacokinetics. Our HPLC results to quantify IF showed adequate intra and inter-day precision (RSD < 15%) and accuracy (RE < 15%) indicating reliability. Also, the administration of GFJ or naringin increased C(max) of IF 22.9% and 17.8%, respectively, and decreased T(max) of IF 19.2 and 53.8%, respectively. The concentration of IF was higher when GFJ (71.35 ± 3.5 µg/mL) was administered with respect to that obtained in the combination naringin with IF (64.12 ± µg/mL); however, the time required to reach such concentration was significantly lower when naringin was administered (p < 0.5). We concluded that pre-administering GFJ and naringin to mice increased the T(max) and decreased the C(max) of IF. Nature Publishing Group UK 2019-11-12 /pmc/articles/PMC6851181/ /pubmed/31719649 http://dx.doi.org/10.1038/s41598-019-53204-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Madrigal-Bujaidar, Eduardo Pérez-Montoya, Edilberto García-Medina, Sandra Cristóbal-Luna, José Melesio Morales-González, José A. Madrigal-Santillán, Eduardo Osiris Paniagua-Pérez, Rogelio Álvarez-González, Isela Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin |
title | Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin |
title_full | Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin |
title_fullStr | Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin |
title_full_unstemmed | Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin |
title_short | Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin |
title_sort | pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851181/ https://www.ncbi.nlm.nih.gov/pubmed/31719649 http://dx.doi.org/10.1038/s41598-019-53204-3 |
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