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Quality of life in idiopathic dystonia: a systematic review

OBJECTIVE: Dystonia is characterised by sustained muscular contractions frequently producing repetitive, twisting and patterned movements. The primary aim of this systematic review was to establish how quality of life (QoL) is affected in idiopathic focal, multifocal and segmental dystonia. This rev...

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Autores principales: Girach, Ayesha, Vinagre Aragon, Ana, Zis, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851210/
https://www.ncbi.nlm.nih.gov/pubmed/30460447
http://dx.doi.org/10.1007/s00415-018-9119-x
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author Girach, Ayesha
Vinagre Aragon, Ana
Zis, Panagiotis
author_facet Girach, Ayesha
Vinagre Aragon, Ana
Zis, Panagiotis
author_sort Girach, Ayesha
collection PubMed
description OBJECTIVE: Dystonia is characterised by sustained muscular contractions frequently producing repetitive, twisting and patterned movements. The primary aim of this systematic review was to establish how quality of life (QoL) is affected in idiopathic focal, multifocal and segmental dystonia. This review aimed to evaluate variations in QoL between different subtypes of dystonia, identify the determinants of QoL and assess the effects of different treatments on QoL. METHODOLOGY: A systematic computer-based literature search was conducted using the PubMed database to search for papers on QoL in idiopathic focal, segmental, multifocal and generalized dystonia. We identified 75 studies meeting our inclusion criteria. Information was extracted regarding prevalence, demographics and response to treatment where indicated. RESULTS: This review revealed QoL to be a significant yet often overlooked issue in idiopathic dystonia. Data consistently showed that dystonia has a negative effect on QoL in patients compared to healthy controls, when measured using disease-specific and generic QoL measures. The majority of studies (n = 25) involved patients with cervical dystonia, followed by benign-essential blepharospasm (n = 10). Along with the beneficial effect to the dystonia symptoms, treatment using Botulinum Toxin and Deep Brain Stimulation is also effective in improving overall QoL across the majority of subtypes. CONCLUSION: The findings demonstrate that patients’ QoL should routinely be assessed and monitored, as this may affect subsequent management. Further research will allow for more robust management of factors contributing to impaired QoL, aside from the physical defects found in dystonia.
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spelling pubmed-68512102019-12-03 Quality of life in idiopathic dystonia: a systematic review Girach, Ayesha Vinagre Aragon, Ana Zis, Panagiotis J Neurol Review OBJECTIVE: Dystonia is characterised by sustained muscular contractions frequently producing repetitive, twisting and patterned movements. The primary aim of this systematic review was to establish how quality of life (QoL) is affected in idiopathic focal, multifocal and segmental dystonia. This review aimed to evaluate variations in QoL between different subtypes of dystonia, identify the determinants of QoL and assess the effects of different treatments on QoL. METHODOLOGY: A systematic computer-based literature search was conducted using the PubMed database to search for papers on QoL in idiopathic focal, segmental, multifocal and generalized dystonia. We identified 75 studies meeting our inclusion criteria. Information was extracted regarding prevalence, demographics and response to treatment where indicated. RESULTS: This review revealed QoL to be a significant yet often overlooked issue in idiopathic dystonia. Data consistently showed that dystonia has a negative effect on QoL in patients compared to healthy controls, when measured using disease-specific and generic QoL measures. The majority of studies (n = 25) involved patients with cervical dystonia, followed by benign-essential blepharospasm (n = 10). Along with the beneficial effect to the dystonia symptoms, treatment using Botulinum Toxin and Deep Brain Stimulation is also effective in improving overall QoL across the majority of subtypes. CONCLUSION: The findings demonstrate that patients’ QoL should routinely be assessed and monitored, as this may affect subsequent management. Further research will allow for more robust management of factors contributing to impaired QoL, aside from the physical defects found in dystonia. Springer Berlin Heidelberg 2018-11-20 2019 /pmc/articles/PMC6851210/ /pubmed/30460447 http://dx.doi.org/10.1007/s00415-018-9119-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Girach, Ayesha
Vinagre Aragon, Ana
Zis, Panagiotis
Quality of life in idiopathic dystonia: a systematic review
title Quality of life in idiopathic dystonia: a systematic review
title_full Quality of life in idiopathic dystonia: a systematic review
title_fullStr Quality of life in idiopathic dystonia: a systematic review
title_full_unstemmed Quality of life in idiopathic dystonia: a systematic review
title_short Quality of life in idiopathic dystonia: a systematic review
title_sort quality of life in idiopathic dystonia: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851210/
https://www.ncbi.nlm.nih.gov/pubmed/30460447
http://dx.doi.org/10.1007/s00415-018-9119-x
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