IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila

Interferon gamma (IFN-γ) restricts the intracellular replication of many pathogens, but the mechanism by which IFN-γ confers cell-intrinsic pathogen resistance remains unclear. For example, intracellular replication of the bacterial pathogen Legionella pneumophila in macrophages is potently curtaile...

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Detalles Bibliográficos
Autores principales: Price, Jordan V., Russo, Daniel, Ji, Daisy X., Chavez, Roberto A., DiPeso, Lucian, Lee, Angus Yiu-Fai, Coers, Jörn, Vance, Russell E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851286/
https://www.ncbi.nlm.nih.gov/pubmed/31719183
http://dx.doi.org/10.1128/mBio.02629-19

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