NusG-Dependent RNA Polymerase Pausing and Tylosin-Dependent Ribosome Stalling Are Required for Tylosin Resistance by Inducing 23S rRNA Methylation in Bacillus subtilis

Macrolide antibiotics bind to 23S rRNA within the peptide exit tunnel of the ribosome, causing the translating ribosome to stall when an appropriately positioned macrolide arrest motif is encountered in the nascent polypeptide. Tylosin is a macrolide antibiotic produced by Streptomyces fradiae. Resi...

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Detalles Bibliográficos
Autores principales: Yakhnin, Helen, Yakhnin, Alexander V., Mouery, Brandon L., Mandell, Zachary F., Karbasiafshar, Catherine, Kashlev, Mikhail, Babitzke, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851288/
https://www.ncbi.nlm.nih.gov/pubmed/31719185
http://dx.doi.org/10.1128/mBio.02665-19

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