LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis

The functions of long (>200 nt) non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) have only been investigated in cancer biology. We found that plasma LncRNA SNHG1 was down-regulated in postmenopausal than in premenopausal females. Among postmenopausal females, the ones with postmeno...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Shuaihao, Zhu, Xiaowen, Xiao, Dan, Zhuang, Jianxiong, Liang, Guoyan, Liang, Changxiang, Zheng, Xiaoqing, Ke, Yuhong, Chang, Yunbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Molecular Bases of Health & Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851504/
https://www.ncbi.nlm.nih.gov/pubmed/31693735
http://dx.doi.org/10.1042/BSR20190445
_version_ 1783469630865539072
author Huang, Shuaihao
Zhu, Xiaowen
Xiao, Dan
Zhuang, Jianxiong
Liang, Guoyan
Liang, Changxiang
Zheng, Xiaoqing
Ke, Yuhong
Chang, Yunbing
author_facet Huang, Shuaihao
Zhu, Xiaowen
Xiao, Dan
Zhuang, Jianxiong
Liang, Guoyan
Liang, Changxiang
Zheng, Xiaoqing
Ke, Yuhong
Chang, Yunbing
author_sort Huang, Shuaihao
collection PubMed
description The functions of long (>200 nt) non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) have only been investigated in cancer biology. We found that plasma LncRNA SNHG1 was down-regulated in postmenopausal than in premenopausal females. Among postmenopausal females, the ones with postmenopausal osteoporosis showed much lower expression levels of plasma lncRNA SNHG1. A 6-year follow-up study on postmenopausal females revealed that plasma lncRNA SNHG1 decreased in females with postmenopausal osteoporosis but not in healthy postmenopausal females. Levels of plasma lncRNA SNHG1 at 12 months before diagnosis is sufficient to distinguish postmenopausal osteoporosis patients from healthy controls. After treatment, plasma lncRNA SNHG1 were significantly up-regulated. Therefore, lncRNA SNHG1 was down-regulated after menopause and plasma level of lncRNA SNHG1 may serve as a biomarker for the diagnosis and treatment of postmenopausal osteoporosis.
format Online
Article
Text
id pubmed-6851504
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-68515042019-11-19 LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis Huang, Shuaihao Zhu, Xiaowen Xiao, Dan Zhuang, Jianxiong Liang, Guoyan Liang, Changxiang Zheng, Xiaoqing Ke, Yuhong Chang, Yunbing Biosci Rep Molecular Bases of Health & Disease The functions of long (>200 nt) non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) have only been investigated in cancer biology. We found that plasma LncRNA SNHG1 was down-regulated in postmenopausal than in premenopausal females. Among postmenopausal females, the ones with postmenopausal osteoporosis showed much lower expression levels of plasma lncRNA SNHG1. A 6-year follow-up study on postmenopausal females revealed that plasma lncRNA SNHG1 decreased in females with postmenopausal osteoporosis but not in healthy postmenopausal females. Levels of plasma lncRNA SNHG1 at 12 months before diagnosis is sufficient to distinguish postmenopausal osteoporosis patients from healthy controls. After treatment, plasma lncRNA SNHG1 were significantly up-regulated. Therefore, lncRNA SNHG1 was down-regulated after menopause and plasma level of lncRNA SNHG1 may serve as a biomarker for the diagnosis and treatment of postmenopausal osteoporosis. Portland Press Ltd. 2019-11-12 /pmc/articles/PMC6851504/ /pubmed/31693735 http://dx.doi.org/10.1042/BSR20190445 Text en © 2019 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Molecular Bases of Health & Disease
Huang, Shuaihao
Zhu, Xiaowen
Xiao, Dan
Zhuang, Jianxiong
Liang, Guoyan
Liang, Changxiang
Zheng, Xiaoqing
Ke, Yuhong
Chang, Yunbing
LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis
title LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis
title_full LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis
title_fullStr LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis
title_full_unstemmed LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis
title_short LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis
title_sort lncrna snhg1 was down-regulated after menopause and participates in postmenopausal osteoporosis
topic Molecular Bases of Health & Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851504/
https://www.ncbi.nlm.nih.gov/pubmed/31693735
http://dx.doi.org/10.1042/BSR20190445
work_keys_str_mv AT huangshuaihao lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT zhuxiaowen lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT xiaodan lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT zhuangjianxiong lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT liangguoyan lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT liangchangxiang lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT zhengxiaoqing lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT keyuhong lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis
AT changyunbing lncrnasnhg1wasdownregulatedaftermenopauseandparticipatesinpostmenopausalosteoporosis

Ejemplares similares