Cargando…
Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS
Genome sequencing (GS) is increasingly being used to diagnose rare diseases in paediatric patients; however, no measures exist to evaluate their knowledge of this technology. We aimed to develop a robust measure of knowledge of GS (the kids‐KOGS') suitable for use in the paediatric setting as w...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851564/ https://www.ncbi.nlm.nih.gov/pubmed/31323115 http://dx.doi.org/10.1111/cge.13607 |
_version_ | 1783469644990906368 |
---|---|
author | Lewis, Celine Loe, Bao S. Sidey‐Gibbons, Chris Patch, Christine Chitty, Lyn S. Sanderson, Saskia C. |
author_facet | Lewis, Celine Loe, Bao S. Sidey‐Gibbons, Chris Patch, Christine Chitty, Lyn S. Sanderson, Saskia C. |
author_sort | Lewis, Celine |
collection | PubMed |
description | Genome sequencing (GS) is increasingly being used to diagnose rare diseases in paediatric patients; however, no measures exist to evaluate their knowledge of this technology. We aimed to develop a robust measure of knowledge of GS (the kids‐KOGS') suitable for use in the paediatric setting as well as for general public education. The target age was 11 to 15 year olds. An iterative process involving six sequential stages was conducted to develop a set of draft true/false items. These were then administered to 539 target‐age school pupils (mean 12.8; SD ± 1.3), from the United Kingdom. Item‐response theory was used to confirm the psychometric suitability of the candidate items. None of the Items was identified as misfits. All 10 items performed well under the two‐parameter logistic model. The internal consistency of the test was 0.84 (Cronbach alpha value) indicating excellent reliability. The mean kids‐KOGS score in the sample overall was 4.24 (SD; 2.49), where 0 = low knowledge and 10 = high knowledge. Age was positively associated with score in a multivariate linear regression. The kids‐KOGS is a short and reliable tool that can be used by researchers and healthcare professionals offering GS to paediatric patients. Further validation in a clinical setting is required. |
format | Online Article Text |
id | pubmed-6851564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-68515642019-11-18 Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS Lewis, Celine Loe, Bao S. Sidey‐Gibbons, Chris Patch, Christine Chitty, Lyn S. Sanderson, Saskia C. Clin Genet Original Articles Genome sequencing (GS) is increasingly being used to diagnose rare diseases in paediatric patients; however, no measures exist to evaluate their knowledge of this technology. We aimed to develop a robust measure of knowledge of GS (the kids‐KOGS') suitable for use in the paediatric setting as well as for general public education. The target age was 11 to 15 year olds. An iterative process involving six sequential stages was conducted to develop a set of draft true/false items. These were then administered to 539 target‐age school pupils (mean 12.8; SD ± 1.3), from the United Kingdom. Item‐response theory was used to confirm the psychometric suitability of the candidate items. None of the Items was identified as misfits. All 10 items performed well under the two‐parameter logistic model. The internal consistency of the test was 0.84 (Cronbach alpha value) indicating excellent reliability. The mean kids‐KOGS score in the sample overall was 4.24 (SD; 2.49), where 0 = low knowledge and 10 = high knowledge. Age was positively associated with score in a multivariate linear regression. The kids‐KOGS is a short and reliable tool that can be used by researchers and healthcare professionals offering GS to paediatric patients. Further validation in a clinical setting is required. Blackwell Publishing Ltd 2019-07-30 2019-11 /pmc/articles/PMC6851564/ /pubmed/31323115 http://dx.doi.org/10.1111/cge.13607 Text en © 2019 The Authors. Clinical Genetics published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Lewis, Celine Loe, Bao S. Sidey‐Gibbons, Chris Patch, Christine Chitty, Lyn S. Sanderson, Saskia C. Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS |
title | Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS |
title_full | Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS |
title_fullStr | Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS |
title_full_unstemmed | Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS |
title_short | Development of a measure of genome sequencing knowledge for young people: The kids‐KOGS |
title_sort | development of a measure of genome sequencing knowledge for young people: the kids‐kogs |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851564/ https://www.ncbi.nlm.nih.gov/pubmed/31323115 http://dx.doi.org/10.1111/cge.13607 |
work_keys_str_mv | AT lewisceline developmentofameasureofgenomesequencingknowledgeforyoungpeoplethekidskogs AT loebaos developmentofameasureofgenomesequencingknowledgeforyoungpeoplethekidskogs AT sideygibbonschris developmentofameasureofgenomesequencingknowledgeforyoungpeoplethekidskogs AT patchchristine developmentofameasureofgenomesequencingknowledgeforyoungpeoplethekidskogs AT chittylyns developmentofameasureofgenomesequencingknowledgeforyoungpeoplethekidskogs AT sandersonsaskiac developmentofameasureofgenomesequencingknowledgeforyoungpeoplethekidskogs |