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Beyond the CRAC: Diversification of ion signaling in B cells
Although calcium signaling and the important role of calcium release–activated calcium channels is well recognized in the context of immune cell signaling, there is a vast diversity of ion channels and transporters that regulate the entry of ions beyond calcium, including magnesium, zinc, potassium,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851625/ https://www.ncbi.nlm.nih.gov/pubmed/31402507 http://dx.doi.org/10.1111/imr.12770 |
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author | Mahtani, Trisha Treanor, Bebhinn |
author_facet | Mahtani, Trisha Treanor, Bebhinn |
author_sort | Mahtani, Trisha |
collection | PubMed |
description | Although calcium signaling and the important role of calcium release–activated calcium channels is well recognized in the context of immune cell signaling, there is a vast diversity of ion channels and transporters that regulate the entry of ions beyond calcium, including magnesium, zinc, potassium, sodium, and chloride. These ions play a critical role in numerous metabolic and cellular processes. The importance of ions in human health and disease is illustrated by the identification of primary immunodeficiencies in patients with mutations in genes encoding ion channels and transporters, as well as the immunological defects observed in individuals with nutritional ion deficiencies. Despite progress in identifying the important role of ions in immune cell development and activation, we are still in the early stages of exploring the diversity of ion channels and transporters and mechanistically understanding the role of these ions in immune cell biology. Here, we review the biology of ion signaling in B cells and the identification of critical ion channels and transporters in B‐cell development, activation, and differentiation into effector cells. Elucidating the role of ion channels and transporters in immune cell signaling is critical for expanding the repertoire of potential therapeutics for the treatment of immune disorders. Moreover, increased understanding of the role of ions in immune cell function will enhance our understanding of the potentially serious consequences of ion deficiencies in human health and disease. |
format | Online Article Text |
id | pubmed-6851625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68516252019-11-18 Beyond the CRAC: Diversification of ion signaling in B cells Mahtani, Trisha Treanor, Bebhinn Immunol Rev Invited Reviews Although calcium signaling and the important role of calcium release–activated calcium channels is well recognized in the context of immune cell signaling, there is a vast diversity of ion channels and transporters that regulate the entry of ions beyond calcium, including magnesium, zinc, potassium, sodium, and chloride. These ions play a critical role in numerous metabolic and cellular processes. The importance of ions in human health and disease is illustrated by the identification of primary immunodeficiencies in patients with mutations in genes encoding ion channels and transporters, as well as the immunological defects observed in individuals with nutritional ion deficiencies. Despite progress in identifying the important role of ions in immune cell development and activation, we are still in the early stages of exploring the diversity of ion channels and transporters and mechanistically understanding the role of these ions in immune cell biology. Here, we review the biology of ion signaling in B cells and the identification of critical ion channels and transporters in B‐cell development, activation, and differentiation into effector cells. Elucidating the role of ion channels and transporters in immune cell signaling is critical for expanding the repertoire of potential therapeutics for the treatment of immune disorders. Moreover, increased understanding of the role of ions in immune cell function will enhance our understanding of the potentially serious consequences of ion deficiencies in human health and disease. John Wiley and Sons Inc. 2019-08-12 2019-09 /pmc/articles/PMC6851625/ /pubmed/31402507 http://dx.doi.org/10.1111/imr.12770 Text en © 2019 The Authors Immunological Reviews Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Reviews Mahtani, Trisha Treanor, Bebhinn Beyond the CRAC: Diversification of ion signaling in B cells |
title | Beyond the CRAC: Diversification of ion signaling in B cells |
title_full | Beyond the CRAC: Diversification of ion signaling in B cells |
title_fullStr | Beyond the CRAC: Diversification of ion signaling in B cells |
title_full_unstemmed | Beyond the CRAC: Diversification of ion signaling in B cells |
title_short | Beyond the CRAC: Diversification of ion signaling in B cells |
title_sort | beyond the crac: diversification of ion signaling in b cells |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851625/ https://www.ncbi.nlm.nih.gov/pubmed/31402507 http://dx.doi.org/10.1111/imr.12770 |
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