Bmi1 Overexpression in Mesenchymal Stem Cells Exerts Antiaging and Antiosteoporosis Effects by Inactivating p16/p19 Signaling and Inhibiting Oxidative Stress

We previously demonstrated that Bmi1 deficiency leads to osteoporosis phenotype by inhibiting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs), but it is unclear whether overexpression of Bmi1 in MSCs stimulates skeletal development and rescues Bmi1 defic...

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Detalles Bibliográficos
Autores principales: Chen, Guangpei, Zhang, Ying, Yu, Shuxiang, Sun, Wen, Miao, Dengshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Tissue‐Specific Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851636/
https://www.ncbi.nlm.nih.gov/pubmed/30895687
http://dx.doi.org/10.1002/stem.3007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851636/
https://www.ncbi.nlm.nih.gov/pubmed/30895687
http://dx.doi.org/10.1002/stem.3007

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