Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828

This editorial highlights a study by Rodriguez, Sanchez‐Moran et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors describe a microcephalic boy carrying the novel heterozygous de novo missense mutation c.560A> G; p.Asp187Gly in Cdh1/Fzr1 encoding the APC/C E3‐...

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Detalles Bibliográficos
Autores principales: Dohrn, Maike F., Bolaños, Juan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Editorial Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851737/
https://www.ncbi.nlm.nih.gov/pubmed/31441503
http://dx.doi.org/10.1111/jnc.14835
Descripción
Sumario:This editorial highlights a study by Rodriguez, Sanchez‐Moran et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors describe a microcephalic boy carrying the novel heterozygous de novo missense mutation c.560A> G; p.Asp187Gly in Cdh1/Fzr1 encoding the APC/C E3‐ubiquitin ligase cofactor CDH1. A functional characterization of mutant APC/C(CDH1) confirms an aberrant division of neural progenitor cells, a condition known to determine the mouse brain cortex size. These data suggest that APC/C(CDH1) may contribute to the regulation of the human brain size. [Image: see text]

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