Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828

This editorial highlights a study by Rodriguez, Sanchez‐Moran et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors describe a microcephalic boy carrying the novel heterozygous de novo missense mutation c.560A> G; p.Asp187Gly in Cdh1/Fzr1 encoding the APC/C E3‐...

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Detalles Bibliográficos
Autores principales: Dohrn, Maike F., Bolaños, Juan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Editorial Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851737/
https://www.ncbi.nlm.nih.gov/pubmed/31441503
http://dx.doi.org/10.1111/jnc.14835
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author Dohrn, Maike F.
Bolaños, Juan P.
author_facet Dohrn, Maike F.
Bolaños, Juan P.
author_sort Dohrn, Maike F.
collection PubMed
description This editorial highlights a study by Rodriguez, Sanchez‐Moran et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors describe a microcephalic boy carrying the novel heterozygous de novo missense mutation c.560A> G; p.Asp187Gly in Cdh1/Fzr1 encoding the APC/C E3‐ubiquitin ligase cofactor CDH1. A functional characterization of mutant APC/C(CDH1) confirms an aberrant division of neural progenitor cells, a condition known to determine the mouse brain cortex size. These data suggest that APC/C(CDH1) may contribute to the regulation of the human brain size. [Image: see text]
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spelling pubmed-68517372019-11-18 Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828 Dohrn, Maike F. Bolaños, Juan P. J Neurochem Editorial Highlight This editorial highlights a study by Rodriguez, Sanchez‐Moran et al. (2019) in the current issue of the Journal of Neurochemistry, in which the authors describe a microcephalic boy carrying the novel heterozygous de novo missense mutation c.560A> G; p.Asp187Gly in Cdh1/Fzr1 encoding the APC/C E3‐ubiquitin ligase cofactor CDH1. A functional characterization of mutant APC/C(CDH1) confirms an aberrant division of neural progenitor cells, a condition known to determine the mouse brain cortex size. These data suggest that APC/C(CDH1) may contribute to the regulation of the human brain size. [Image: see text] John Wiley and Sons Inc. 2019-08-23 2019-10 /pmc/articles/PMC6851737/ /pubmed/31441503 http://dx.doi.org/10.1111/jnc.14835 Text en © 2019 The Authors Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial Highlight
Dohrn, Maike F.
Bolaños, Juan P.
Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828
title Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828
title_full Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828
title_fullStr Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828
title_full_unstemmed Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828
title_short Does APC/C(CDH1) control the human brain size?: An Editorial Highlight for https://doi.org/10.1111/jnc.14828
title_sort does apc/c(cdh1) control the human brain size?: an editorial highlight for https://doi.org/10.1111/jnc.14828
topic Editorial Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851737/
https://www.ncbi.nlm.nih.gov/pubmed/31441503
http://dx.doi.org/10.1111/jnc.14835
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