Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates

Requirements for novel bioconjugation reactions for the synthesis of antibody–drug conjugates (ADCs) are exceptionally high, since conjugation selectivity as well as the stability and hydrophobicity of linkers and payloads drastically influence the performance and safety profile of the final product...

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Detalles Bibliográficos
Autores principales: Kasper, Marc‐André, Stengl, Andreas, Ochtrop, Philipp, Gerlach, Marcus, Stoschek, Tina, Schumacher, Dominik, Helma, Jonas, Penkert, Martin, Krause, Eberhard, Leonhardt, Heinrich, Hackenberger, Christian P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851832/
https://www.ncbi.nlm.nih.gov/pubmed/31250955
http://dx.doi.org/10.1002/anie.201904193

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