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Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017

OBJECTIVE: To examine the results of the Malaysian Advanced Prostate Cancer Consensus Conference (MyAPCCC) 2018, held for assessing the generalizability of consensus reached at the Advanced Prostate Cancer Consensus Conference (APCCC 2017) to Malaysia, a middle‐income country. METHODS: Six key secti...

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Autores principales: Saad, Marniza, Alip, Adlinda, Lim, Jasmine, Abdullah, Matin Mellor, Chong, Flora Li Tze, Chua, Chong Beng, Ismail, Fuad, Khong, Rachael Kit‐Tsan, Lim, Chun Sen, Loh, Chit Sin, Malek, Rohan, Mohd Ghani, Khairul Asri, Md Noor, Ibtisam, Md Yusoff, Noor Ashani, Nasuha, Noor Azam, Razack, Azad, Soo Hoo, Hwoei Fen, Sundram, Murali, Tan, Hui Meng, Thiagarajan, Muthukkumaran, Teh, Guan Chou, Voon, Pei Jye, Ong, Teng Aik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851975/
https://www.ncbi.nlm.nih.gov/pubmed/31077523
http://dx.doi.org/10.1111/bju.14807
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author Saad, Marniza
Alip, Adlinda
Lim, Jasmine
Abdullah, Matin Mellor
Chong, Flora Li Tze
Chua, Chong Beng
Ismail, Fuad
Khong, Rachael Kit‐Tsan
Lim, Chun Sen
Loh, Chit Sin
Malek, Rohan
Mohd Ghani, Khairul Asri
Md Noor, Ibtisam
Md Yusoff, Noor Ashani
Nasuha, Noor Azam
Razack, Azad
Soo Hoo, Hwoei Fen
Sundram, Murali
Tan, Hui Meng
Thiagarajan, Muthukkumaran
Teh, Guan Chou
Voon, Pei Jye
Ong, Teng Aik
author_facet Saad, Marniza
Alip, Adlinda
Lim, Jasmine
Abdullah, Matin Mellor
Chong, Flora Li Tze
Chua, Chong Beng
Ismail, Fuad
Khong, Rachael Kit‐Tsan
Lim, Chun Sen
Loh, Chit Sin
Malek, Rohan
Mohd Ghani, Khairul Asri
Md Noor, Ibtisam
Md Yusoff, Noor Ashani
Nasuha, Noor Azam
Razack, Azad
Soo Hoo, Hwoei Fen
Sundram, Murali
Tan, Hui Meng
Thiagarajan, Muthukkumaran
Teh, Guan Chou
Voon, Pei Jye
Ong, Teng Aik
author_sort Saad, Marniza
collection PubMed
description OBJECTIVE: To examine the results of the Malaysian Advanced Prostate Cancer Consensus Conference (MyAPCCC) 2018, held for assessing the generalizability of consensus reached at the Advanced Prostate Cancer Consensus Conference (APCCC 2017) to Malaysia, a middle‐income country. METHODS: Six key sections were chosen: (1) high‐risk localized and locally advanced prostate cancer, (2) oligometastatic prostate cancer, (3) castration‐naïve prostate cancer, (4) castrate resistant prostate cancer, (5) use of osteoclast‐targeted therapy and (6) global access to prostate cancer drugs. There were 101 consensus questions, consisting of 91 questions from APCCC 2017 and 10 new questions from MyAPCCC 2018, selected and modified by the steering committee; of which, 23 questions were assessed in both ideal world and real‐world settings. A panel of 22 experts, comprising of 11 urologists and 11 oncologists, voted on 101 predefined questions anonymously. Final voting results were compared with the APCCC 2017 outcomes. RESULTS: Most voting results from the MyAPCCC 2018 were consistent with the APCCC 2017 outcomes. No consensus was achieved for controversial topics with little level I evidence, such as management of oligometastatic disease. No consensus was reached on using high‐cost drugs in castration‐naïve or castration‐resistant metastatic prostate cancer in real‐world settings. All panellists recommended using generic drugs when available. CONCLUSIONS: The MyAPCCC 2018 voting results reflect the management of advanced prostate cancer in a middle‐income country in a real‐world setting. These results may serve as a guide for local clinical practices and highlight the financial challenges in modern healthcare.
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spelling pubmed-68519752019-11-18 Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017 Saad, Marniza Alip, Adlinda Lim, Jasmine Abdullah, Matin Mellor Chong, Flora Li Tze Chua, Chong Beng Ismail, Fuad Khong, Rachael Kit‐Tsan Lim, Chun Sen Loh, Chit Sin Malek, Rohan Mohd Ghani, Khairul Asri Md Noor, Ibtisam Md Yusoff, Noor Ashani Nasuha, Noor Azam Razack, Azad Soo Hoo, Hwoei Fen Sundram, Murali Tan, Hui Meng Thiagarajan, Muthukkumaran Teh, Guan Chou Voon, Pei Jye Ong, Teng Aik BJU Int Reviews OBJECTIVE: To examine the results of the Malaysian Advanced Prostate Cancer Consensus Conference (MyAPCCC) 2018, held for assessing the generalizability of consensus reached at the Advanced Prostate Cancer Consensus Conference (APCCC 2017) to Malaysia, a middle‐income country. METHODS: Six key sections were chosen: (1) high‐risk localized and locally advanced prostate cancer, (2) oligometastatic prostate cancer, (3) castration‐naïve prostate cancer, (4) castrate resistant prostate cancer, (5) use of osteoclast‐targeted therapy and (6) global access to prostate cancer drugs. There were 101 consensus questions, consisting of 91 questions from APCCC 2017 and 10 new questions from MyAPCCC 2018, selected and modified by the steering committee; of which, 23 questions were assessed in both ideal world and real‐world settings. A panel of 22 experts, comprising of 11 urologists and 11 oncologists, voted on 101 predefined questions anonymously. Final voting results were compared with the APCCC 2017 outcomes. RESULTS: Most voting results from the MyAPCCC 2018 were consistent with the APCCC 2017 outcomes. No consensus was achieved for controversial topics with little level I evidence, such as management of oligometastatic disease. No consensus was reached on using high‐cost drugs in castration‐naïve or castration‐resistant metastatic prostate cancer in real‐world settings. All panellists recommended using generic drugs when available. CONCLUSIONS: The MyAPCCC 2018 voting results reflect the management of advanced prostate cancer in a middle‐income country in a real‐world setting. These results may serve as a guide for local clinical practices and highlight the financial challenges in modern healthcare. John Wiley and Sons Inc. 2019-06-17 2019-09 /pmc/articles/PMC6851975/ /pubmed/31077523 http://dx.doi.org/10.1111/bju.14807 Text en © 2019 The Authors BJU International © 2019 BJU International Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Reviews
Saad, Marniza
Alip, Adlinda
Lim, Jasmine
Abdullah, Matin Mellor
Chong, Flora Li Tze
Chua, Chong Beng
Ismail, Fuad
Khong, Rachael Kit‐Tsan
Lim, Chun Sen
Loh, Chit Sin
Malek, Rohan
Mohd Ghani, Khairul Asri
Md Noor, Ibtisam
Md Yusoff, Noor Ashani
Nasuha, Noor Azam
Razack, Azad
Soo Hoo, Hwoei Fen
Sundram, Murali
Tan, Hui Meng
Thiagarajan, Muthukkumaran
Teh, Guan Chou
Voon, Pei Jye
Ong, Teng Aik
Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017
title Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017
title_full Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017
title_fullStr Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017
title_full_unstemmed Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017
title_short Management of advanced prostate cancer in a middle‐income country: real‐world consideration of the Advanced Prostate Cancer Consensus Conference 2017
title_sort management of advanced prostate cancer in a middle‐income country: real‐world consideration of the advanced prostate cancer consensus conference 2017
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851975/
https://www.ncbi.nlm.nih.gov/pubmed/31077523
http://dx.doi.org/10.1111/bju.14807
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