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Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs

OBJECTIVES: To measure serum leptin concentration in dogs with pituitary‐dependent hyperadrenocorticism and varying degrees of cholestatic disease and determine whether serum levels differed between dogs with pituitary‐dependent hyperadrenocorticism and those with gall bladder mucocoele. MATERIALS A...

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Autores principales: Lee, S., Kweon, O.‐K., Kim, W. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852161/
https://www.ncbi.nlm.nih.gov/pubmed/31276206
http://dx.doi.org/10.1111/jsap.13044
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author Lee, S.
Kweon, O.‐K.
Kim, W. H.
author_facet Lee, S.
Kweon, O.‐K.
Kim, W. H.
author_sort Lee, S.
collection PubMed
description OBJECTIVES: To measure serum leptin concentration in dogs with pituitary‐dependent hyperadrenocorticism and varying degrees of cholestatic disease and determine whether serum levels differed between dogs with pituitary‐dependent hyperadrenocorticism and those with gall bladder mucocoele. MATERIALS AND METHODS: Client‐owned healthy dogs (n=20), dogs diagnosed with gall bladder mucocoele (n=20) and dogs diagnosed with pituitary‐dependent hyperadrenocorticism (n=60) were enrolled. Only dogs of normal body condition score were included. Dogs with pituitary‐dependent hyperadrenocorticism were divided into three groups according to the severity of cholestatic disease: normal gall bladder (n=20), cholestasis (n=20) and gall bladder mucocoele (n=20). Serum leptin levels were measured using sandwich enzyme‐linked immunosorbent assay. RESULTS: Serum concentrations of leptin were similar between dogs with gall bladder mucocoele and those with pituitary‐dependent hyperadrenocorticism accompanied by gall bladder mucocoele; these concentrations were significantly higher than those in healthy control dogs. In dogs with pituitary‐dependent hyperadrenocorticism, circulating leptin concentration significantly increased with the severity of cholestasis: higher in the cholestasis group than the normal gall bladder group and higher in the gall bladder mucocoele group than the cholestasis group. CLINICAL SIGNIFICANCE: Elevated circulating leptin concentration was associated with canine pituitary‐dependent hyperadrenocorticism and gall bladder mucocoele. Homeostatic imbalance of leptin concentration might be associated with severity of cholestatic disease in pituitary‐dependent hyperadrenocorticism.
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spelling pubmed-68521612019-11-22 Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs Lee, S. Kweon, O.‐K. Kim, W. H. J Small Anim Pract Papers OBJECTIVES: To measure serum leptin concentration in dogs with pituitary‐dependent hyperadrenocorticism and varying degrees of cholestatic disease and determine whether serum levels differed between dogs with pituitary‐dependent hyperadrenocorticism and those with gall bladder mucocoele. MATERIALS AND METHODS: Client‐owned healthy dogs (n=20), dogs diagnosed with gall bladder mucocoele (n=20) and dogs diagnosed with pituitary‐dependent hyperadrenocorticism (n=60) were enrolled. Only dogs of normal body condition score were included. Dogs with pituitary‐dependent hyperadrenocorticism were divided into three groups according to the severity of cholestatic disease: normal gall bladder (n=20), cholestasis (n=20) and gall bladder mucocoele (n=20). Serum leptin levels were measured using sandwich enzyme‐linked immunosorbent assay. RESULTS: Serum concentrations of leptin were similar between dogs with gall bladder mucocoele and those with pituitary‐dependent hyperadrenocorticism accompanied by gall bladder mucocoele; these concentrations were significantly higher than those in healthy control dogs. In dogs with pituitary‐dependent hyperadrenocorticism, circulating leptin concentration significantly increased with the severity of cholestasis: higher in the cholestasis group than the normal gall bladder group and higher in the gall bladder mucocoele group than the cholestasis group. CLINICAL SIGNIFICANCE: Elevated circulating leptin concentration was associated with canine pituitary‐dependent hyperadrenocorticism and gall bladder mucocoele. Homeostatic imbalance of leptin concentration might be associated with severity of cholestatic disease in pituitary‐dependent hyperadrenocorticism. Blackwell Publishing Ltd 2019-07-05 2019-10 /pmc/articles/PMC6852161/ /pubmed/31276206 http://dx.doi.org/10.1111/jsap.13044 Text en © 2019 The Authors Journal of Small Animal Practice published by John Wiley & Sons Ltd on behalf of British Small Animal Veterinary Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Papers
Lee, S.
Kweon, O.‐K.
Kim, W. H.
Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs
title Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs
title_full Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs
title_fullStr Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs
title_full_unstemmed Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs
title_short Relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs
title_sort relationship of serum leptin concentration with pituitary‐dependent hyperadrenocorticism and cholestatic disease in dogs
topic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852161/
https://www.ncbi.nlm.nih.gov/pubmed/31276206
http://dx.doi.org/10.1111/jsap.13044
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