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Motor lumbosacral radiculopathy in HIV-infected patients

BACKGROUND: This study is a review of the clinical findings and treatment outcome of 11 HIV-infected patients with motor lumbosacral radiculopathy. OBJECTIVES: To describe the clinical, laboratory, electrophysiological features and treatment outcome in HIV-infected motor lumbosacral radiculopathy wh...

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Autores principales: Moodley, Kaminie, Bill, Pierre L.A., Patel, Vinod B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852262/
https://www.ncbi.nlm.nih.gov/pubmed/31745432
http://dx.doi.org/10.4102/sajhivmed.v20i1.992
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author Moodley, Kaminie
Bill, Pierre L.A.
Patel, Vinod B.
author_facet Moodley, Kaminie
Bill, Pierre L.A.
Patel, Vinod B.
author_sort Moodley, Kaminie
collection PubMed
description BACKGROUND: This study is a review of the clinical findings and treatment outcome of 11 HIV-infected patients with motor lumbosacral radiculopathy. OBJECTIVES: To describe the clinical, laboratory, electrophysiological features and treatment outcome in HIV-infected motor lumbosacral radiculopathy which is a rare manifestation of HIV. METHOD: A retrospective review of HIV-infected patients with motor lumbosacral radiculopathy was performed at Inkosi Albert Luthuli Central Hospital (IALCH), Durban, South Africa between 2010 and 2015. RESULTS: Eleven black African patients met the inclusion criteria. There were six women. The median age was 29 years, the interquartile range (IQR) was 23–41 years, the median duration of symptom progression was 6.5 months (IQR 3–7.5 months). The median CD4 count was 327 cells/µL (IQR 146–457). The cerebrospinal fluid (CSF) median polymorphocyte count was 0 cells/µL (IQR 0 cells/µL – 2 cells/µL), lymphocyte count was 16 cells/µL (IQR 1 cells/µL – 18 cells/µL), glucose level was 3.1 mmol/L (IQR 2.8 mmol/L – 3.4 mmol/L) and protein level was 1.02 g/dL (IQR 0.98 g/dL – 3.4 g/dL). All patients were treated with corticosteroid therapy. Ninety-one per cent recovered fully within 6 months of treatment, the median time for recovery was 3.4 months (IQR 1.8–5.6 months). There were no relapses during the 18-month follow-up. CONCLUSION: HIV-infected patients with motor lumbosacral radiculopathy responded to corticosteroids, with no relapses during the 18-month follow-up period.
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spelling pubmed-68522622019-11-19 Motor lumbosacral radiculopathy in HIV-infected patients Moodley, Kaminie Bill, Pierre L.A. Patel, Vinod B. South Afr J HIV Med Original Research BACKGROUND: This study is a review of the clinical findings and treatment outcome of 11 HIV-infected patients with motor lumbosacral radiculopathy. OBJECTIVES: To describe the clinical, laboratory, electrophysiological features and treatment outcome in HIV-infected motor lumbosacral radiculopathy which is a rare manifestation of HIV. METHOD: A retrospective review of HIV-infected patients with motor lumbosacral radiculopathy was performed at Inkosi Albert Luthuli Central Hospital (IALCH), Durban, South Africa between 2010 and 2015. RESULTS: Eleven black African patients met the inclusion criteria. There were six women. The median age was 29 years, the interquartile range (IQR) was 23–41 years, the median duration of symptom progression was 6.5 months (IQR 3–7.5 months). The median CD4 count was 327 cells/µL (IQR 146–457). The cerebrospinal fluid (CSF) median polymorphocyte count was 0 cells/µL (IQR 0 cells/µL – 2 cells/µL), lymphocyte count was 16 cells/µL (IQR 1 cells/µL – 18 cells/µL), glucose level was 3.1 mmol/L (IQR 2.8 mmol/L – 3.4 mmol/L) and protein level was 1.02 g/dL (IQR 0.98 g/dL – 3.4 g/dL). All patients were treated with corticosteroid therapy. Ninety-one per cent recovered fully within 6 months of treatment, the median time for recovery was 3.4 months (IQR 1.8–5.6 months). There were no relapses during the 18-month follow-up. CONCLUSION: HIV-infected patients with motor lumbosacral radiculopathy responded to corticosteroids, with no relapses during the 18-month follow-up period. AOSIS 2019-10-28 /pmc/articles/PMC6852262/ /pubmed/31745432 http://dx.doi.org/10.4102/sajhivmed.v20i1.992 Text en © 2019. The Authors https://creativecommons.org/licenses/by/4.0/ Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.
spellingShingle Original Research
Moodley, Kaminie
Bill, Pierre L.A.
Patel, Vinod B.
Motor lumbosacral radiculopathy in HIV-infected patients
title Motor lumbosacral radiculopathy in HIV-infected patients
title_full Motor lumbosacral radiculopathy in HIV-infected patients
title_fullStr Motor lumbosacral radiculopathy in HIV-infected patients
title_full_unstemmed Motor lumbosacral radiculopathy in HIV-infected patients
title_short Motor lumbosacral radiculopathy in HIV-infected patients
title_sort motor lumbosacral radiculopathy in hiv-infected patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852262/
https://www.ncbi.nlm.nih.gov/pubmed/31745432
http://dx.doi.org/10.4102/sajhivmed.v20i1.992
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