Cargando…

Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough

BACKGROUND: Many cystic fibrosis (CF) patients chronically infected with Pseudomonas aeruginosa are on maintenance tobramycin inhalation therapy. Cough is reported as a side effect of tobramycin inhalation powder (TIP) in 48% of the patients. Objectives of this study were to investigate the associat...

Descripción completa

Detalles Bibliográficos
Autores principales: Meerburg, Jennifer J., Albasri, Mehdi, van der Wiel, Els C., Andrinopoulou, Eleni‐Rosalina, van der Eerden, Menno M., Majoor, Christof J., Arets, Hubertus G.M., Heijerman, Harry G.M., Tiddens, Harm A.W.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852538/
https://www.ncbi.nlm.nih.gov/pubmed/31393073
http://dx.doi.org/10.1002/ppul.24467
_version_ 1783469860798332928
author Meerburg, Jennifer J.
Albasri, Mehdi
van der Wiel, Els C.
Andrinopoulou, Eleni‐Rosalina
van der Eerden, Menno M.
Majoor, Christof J.
Arets, Hubertus G.M.
Heijerman, Harry G.M.
Tiddens, Harm A.W.M.
author_facet Meerburg, Jennifer J.
Albasri, Mehdi
van der Wiel, Els C.
Andrinopoulou, Eleni‐Rosalina
van der Eerden, Menno M.
Majoor, Christof J.
Arets, Hubertus G.M.
Heijerman, Harry G.M.
Tiddens, Harm A.W.M.
author_sort Meerburg, Jennifer J.
collection PubMed
description BACKGROUND: Many cystic fibrosis (CF) patients chronically infected with Pseudomonas aeruginosa are on maintenance tobramycin inhalation therapy. Cough is reported as a side effect of tobramycin inhalation powder (TIP) in 48% of the patients. Objectives of this study were to investigate the association between the inspiratory flow of TIP and cough and to study the inhalation technique. We hypothesized that cough is related to a fast inhalation. MATERIALS AND METHODS: In this prospective observational study, CF patients ≥ 6 years old on TIP maintenance therapy from four Dutch CF centers were visited twice at home. Video recordings were obtained and peak inspiratory flow (PIF) was recorded while patients inhaled TIP. Between the two home visits, the patients made three additional videos. CF questionnaire‐revised, spirometry data, and computed tomography scan were collected. Two observers scored the videos for PIF, cough, and mistakes in inhalation technique. The associations between PIF and cough were analyzed using a logistic mixed‐effects model accounting for FEV(1)% predicted and capsule number. RESULTS: Twenty patients were included, median age 22 (18–28) years. No significant associations were found between PIF and cough. The risk of cough was highest after inhalation of the first capsule when compared to the second, third, and fourth capsule (P ≤ .015). Fourteen patients (70%) coughed at least once during TIP inhalation. A breath‐hold of less than 5 seconds after inhalation and no deep expiration before inhalation were the most commonly observed mistakes. CONCLUSION: PIF is not related to cough in CF patients using TIP.
format Online
Article
Text
id pubmed-6852538
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-68525382019-11-20 Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough Meerburg, Jennifer J. Albasri, Mehdi van der Wiel, Els C. Andrinopoulou, Eleni‐Rosalina van der Eerden, Menno M. Majoor, Christof J. Arets, Hubertus G.M. Heijerman, Harry G.M. Tiddens, Harm A.W.M. Pediatr Pulmonol ORIGINAL ARTICLES BACKGROUND: Many cystic fibrosis (CF) patients chronically infected with Pseudomonas aeruginosa are on maintenance tobramycin inhalation therapy. Cough is reported as a side effect of tobramycin inhalation powder (TIP) in 48% of the patients. Objectives of this study were to investigate the association between the inspiratory flow of TIP and cough and to study the inhalation technique. We hypothesized that cough is related to a fast inhalation. MATERIALS AND METHODS: In this prospective observational study, CF patients ≥ 6 years old on TIP maintenance therapy from four Dutch CF centers were visited twice at home. Video recordings were obtained and peak inspiratory flow (PIF) was recorded while patients inhaled TIP. Between the two home visits, the patients made three additional videos. CF questionnaire‐revised, spirometry data, and computed tomography scan were collected. Two observers scored the videos for PIF, cough, and mistakes in inhalation technique. The associations between PIF and cough were analyzed using a logistic mixed‐effects model accounting for FEV(1)% predicted and capsule number. RESULTS: Twenty patients were included, median age 22 (18–28) years. No significant associations were found between PIF and cough. The risk of cough was highest after inhalation of the first capsule when compared to the second, third, and fourth capsule (P ≤ .015). Fourteen patients (70%) coughed at least once during TIP inhalation. A breath‐hold of less than 5 seconds after inhalation and no deep expiration before inhalation were the most commonly observed mistakes. CONCLUSION: PIF is not related to cough in CF patients using TIP. John Wiley and Sons Inc. 2019-08-08 2019-11 /pmc/articles/PMC6852538/ /pubmed/31393073 http://dx.doi.org/10.1002/ppul.24467 Text en © 2019 The Authors. Pediatric Pulmonology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle ORIGINAL ARTICLES
Meerburg, Jennifer J.
Albasri, Mehdi
van der Wiel, Els C.
Andrinopoulou, Eleni‐Rosalina
van der Eerden, Menno M.
Majoor, Christof J.
Arets, Hubertus G.M.
Heijerman, Harry G.M.
Tiddens, Harm A.W.M.
Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough
title Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough
title_full Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough
title_fullStr Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough
title_full_unstemmed Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough
title_short Home videos of cystic fibrosis patients using tobramycin inhalation powder: Relation of flow and cough
title_sort home videos of cystic fibrosis patients using tobramycin inhalation powder: relation of flow and cough
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852538/
https://www.ncbi.nlm.nih.gov/pubmed/31393073
http://dx.doi.org/10.1002/ppul.24467
work_keys_str_mv AT meerburgjenniferj homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT albasrimehdi homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT vanderwielelsc homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT andrinopoulouelenirosalina homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT vandereerdenmennom homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT majoorchristofj homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT aretshubertusgm homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT heijermanharrygm homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough
AT tiddensharmawm homevideosofcysticfibrosispatientsusingtobramycininhalationpowderrelationofflowandcough