Cargando…

Frontline Science: Endotoxin‐induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst

Secondary infections are a major complication of sepsis and associated with a compromised immune state, called sepsis‐induced immunoparalysis. Molecular mechanisms causing immunoparalysis remain unclear; however, changes in cellular metabolism of leukocytes have been linked to immunoparalysis. We in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grondman, Inge, Arts, Rob J. W., Koch, Rebecca M., Leijte, Guus P., Gerretsen, Jelle, Bruse, Niklas, Kempkes, Rosalie W. M., ter Horst, Rob, Kox, Matthijs, Pickkers, Peter, Netea, Mihai G., Gresnigt, Mark S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Spotlight on Leading Edge Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852552/ https://www.ncbi.nlm.nih.gov/pubmed/31169935 http://dx.doi.org/10.1002/JLB.5HI0119-018R

Ejemplares similares

Comparison of different lots of endotoxin and evaluation of in vivo potency over time in the experimental human endotoxemia model
por: Kiers, Dorien, et al.
Publicado: (2019)

Frontline Science: Employing enzymatic treatment options for management of ocular biofilm‐based infections
por: Kugadas, Abirami, et al.
Publicado: (2019)

Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish
por: Sommer, Frida, et al.
Publicado: (2019)

Frontline Science: LPS‐inducible SLC30A1 drives human macrophage‐mediated zinc toxicity against intracellular Escherichia coli
por: Stocks, Claudia J., et al.
Publicado: (2020)

Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
por: Standing, Ariane S. I., et al.
Publicado: (2017)

Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses
por: Suire, Sabine, et al.
Publicado: (2019)

Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study
por: Leijte, Guus P., et al.
Publicado: (2019)

Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia
por: Ferreira, Anaísa V., et al.
Publicado: (2021)

The use of chromoendoscopy for surveillance of inflammatory bowel disease
por: Lichtenstein, Gary R., et al.
Publicado: (2018)

Trade in wild animals: a disaster ignored
por: The Lancet Infectious Diseases
Publicado: (2003)

A European CDC
por: The Lancet Infectious Diseases
Publicado: (2003)

An appropriate response to SARS
por: The Lancet Infectious Diseases
Publicado: (2003)

Making our hospitals healthier places
por: The Lancet Infectious Diseases
Publicado: (2004)

Original research in The Lancet Infectious Diseases
por: The Lancet Infectious Diseases
Publicado: (2010)

Are you ready for the next influenza pandemic?
por: The Lancet Infectious Diseases
Publicado: (2005)

A new public health world order
por: The Lancet Infectious Diseases
Publicado: (2004)

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
por: McGrath, Emmet E., et al.
Publicado: (2011)

Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-β
por: Willet, Joseph D. P., et al.
Publicado: (2013)

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators
por: Raza, Sobia, et al.
Publicado: (2014)

Langerin-expressing dendritic cells in human tissues are related to CD1c(+) dendritic cells and distinct from Langerhans cells and CD141(high) XCR1(+) dendritic cells
por: Bigley, Venetia, et al.
Publicado: (2015)

IL‐4 induces a suppressive IL‐10‐producing CD8(+) T cell population via a Cdkn2a‐dependent mechanism
por: Zhao, Yapu, et al.
Publicado: (2013)

The cation channel TRPM8 influences the differentiation and function of human monocytes
por: Hornsby, Eve, et al.
Publicado: (2022)

Antiretroviral therapy restores the homeostatic state of microglia in SIV‐infected rhesus macaques
por: Trease, Andrew J., et al.
Publicado: (2022)

Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes
por: Ashby, Louisa V, et al.
Publicado: (2022)

A randomized double‐blind, placebo‐controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA‐230 during experimental human endotoxaemia
por: van Groenendael, Roger, et al.
Publicado: (2019)

Fever in Sepsis: Still a Hot Topic
por: Leijte, Guus Pieter, et al.
Publicado: (2019)

Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
por: Leijte, Guus P., et al.
Publicado: (2018)

Are anticoagulants still indicated in pulmonary arterial hypertension?
por: Olschewski, Horst, et al.
Publicado: (2018)

Early intervention: should we conduct therapeutic trials for mild pulmonary hypertension before onset of symptoms?
por: Huston, Jessica H., et al.
Publicado: (2019)

United States Pulmonary Hypertension Scientific Registry (USPHSR): rationale, design, and clinical implications
por: Elliott, C. Gregory, et al.
Publicado: (2019)

Extracellular vesicles released from p18 overexpressing pulmonary endothelial cells are barrier protective – potential implications for acute respiratory distress syndrome
por: Harrington, Elizabeth O., et al.
Publicado: (2020)

Pulmonary vasodilators: beyond the bounds of pulmonary arterial hypertension therapy in COVID-19
por: Franco, Veronica, et al.
Publicado: (2020)

Transplanting COVID-19–Positive Donor Hearts: A Previous Threat, Now an Opportunity
por: Schlendorf, Kelly H., et al.
Publicado: (2023)

Precision Medicine: Solving the Mystery of Myocarditis in the Aftermath of SARS-CoV-2
por: Feldman, Arthur M., et al.
Publicado: (2023)

Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance
por: Jansen, Aron, et al.
Publicado: (2022)

The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
por: Leentjens, Jenneke, et al.
Publicado: (2014)

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes
por: Leijte, Guus P., et al.
Publicado: (2020)

Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients
por: Beunders, Remi, et al.
Publicado: (2020)

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo
por: Koch, Rebecca M., et al.
Publicado: (2017)

Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure
por: Byrne, Nikole J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dlqvhalf3aff4u285pbp03nsk7