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End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium
Titin functions as a molecular spring, and cardiomyocytes are able, through splicing, to control the length of titin. We hypothesized that together with diastolic [Ca(2+)], titin‐based stretch pre‐activates cardiomyocytes during diastole and is a major determinant of force production in the subseque...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852589/ https://www.ncbi.nlm.nih.gov/pubmed/31314138 http://dx.doi.org/10.1113/JP277985 |