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Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana

Medical records and residual samples from 334 type 2 diabetes mellitus patients attending a clinic in Gaborone, Botswana, during the period September–December 2016 were analysed for the effects of hyperuricaemia on biochemical markers of adverse outcomes. The patients were stratified as having hyper...

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Autores principales: Gobusamang, Ellen, Nyepetsi, Naledi G., Motswaledi, Modisa S., Kasvosve, Ishmael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AOSIS 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852606/
https://www.ncbi.nlm.nih.gov/pubmed/31745455
http://dx.doi.org/10.4102/ajlm.v8i1.786
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author Gobusamang, Ellen
Nyepetsi, Naledi G.
Motswaledi, Modisa S.
Kasvosve, Ishmael
author_facet Gobusamang, Ellen
Nyepetsi, Naledi G.
Motswaledi, Modisa S.
Kasvosve, Ishmael
author_sort Gobusamang, Ellen
collection PubMed
description Medical records and residual samples from 334 type 2 diabetes mellitus patients attending a clinic in Gaborone, Botswana, during the period September–December 2016 were analysed for the effects of hyperuricaemia on biochemical markers of adverse outcomes. The patients were stratified as having hyperuricaemia (> 400 µmol/L) or normal serum uric acid (≤ 400 µmol/L). We compared glycated haemoglobin, triglycerides, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, total cholesterol and serum creatinine between the two serum uric acid categories. Hyperuricaemia was detected in 28% of patients (95% confidence interval 23.1–32.9) and was associated with increased serum triglycerides, triglyceride to high-density lipoprotein-cholesterol ratio and creatinine concentration, but not with glycated haemoglobin.
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spelling pubmed-68526062019-11-19 Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana Gobusamang, Ellen Nyepetsi, Naledi G. Motswaledi, Modisa S. Kasvosve, Ishmael Afr J Lab Med Brief Report Medical records and residual samples from 334 type 2 diabetes mellitus patients attending a clinic in Gaborone, Botswana, during the period September–December 2016 were analysed for the effects of hyperuricaemia on biochemical markers of adverse outcomes. The patients were stratified as having hyperuricaemia (> 400 µmol/L) or normal serum uric acid (≤ 400 µmol/L). We compared glycated haemoglobin, triglycerides, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, total cholesterol and serum creatinine between the two serum uric acid categories. Hyperuricaemia was detected in 28% of patients (95% confidence interval 23.1–32.9) and was associated with increased serum triglycerides, triglyceride to high-density lipoprotein-cholesterol ratio and creatinine concentration, but not with glycated haemoglobin. AOSIS 2019-11-07 /pmc/articles/PMC6852606/ /pubmed/31745455 http://dx.doi.org/10.4102/ajlm.v8i1.786 Text en © 2019. The Authors https://creativecommons.org/licenses/by/4.0/ Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.
spellingShingle Brief Report
Gobusamang, Ellen
Nyepetsi, Naledi G.
Motswaledi, Modisa S.
Kasvosve, Ishmael
Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana
title Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana
title_full Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana
title_fullStr Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana
title_full_unstemmed Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana
title_short Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana
title_sort hyperuricaemia is associated with dyslipidemia but not hba1c among type 2 diabetes mellitus patients in botswana
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852606/
https://www.ncbi.nlm.nih.gov/pubmed/31745455
http://dx.doi.org/10.4102/ajlm.v8i1.786
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