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Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma
BACKGROUND: Glioma, most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Evaluate the association of polymorphisms related of to the cell cycle, integrity and DNA repair with gliomas, as well as lifestyle habits, comorbidities, survival and...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852820/ https://www.ncbi.nlm.nih.gov/pubmed/31450905 http://dx.doi.org/10.31557/APJCP.2019.20.8.2345 |
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author | Jessica Calastri, Maria Clara Hattori, Gabriela Toledo Ortega Rodrigues, Nicolas Luz Lima Gregório, Michele Oliveira Brancati, Camila Ive Ferreira Milharcix Zanovelo, Eliane Lopes Ferraz Filho, José Roberto Merussi Neiva, Cassiano Ponde Rodrigues Junior, Antonio Carlos de Godoy, Moacir Fernandes Penteado Lancellotti, Carmen Lucia Antonio Tognola, Waldir Silva Souza, Dorotéia Rossi |
author_facet | Jessica Calastri, Maria Clara Hattori, Gabriela Toledo Ortega Rodrigues, Nicolas Luz Lima Gregório, Michele Oliveira Brancati, Camila Ive Ferreira Milharcix Zanovelo, Eliane Lopes Ferraz Filho, José Roberto Merussi Neiva, Cassiano Ponde Rodrigues Junior, Antonio Carlos de Godoy, Moacir Fernandes Penteado Lancellotti, Carmen Lucia Antonio Tognola, Waldir Silva Souza, Dorotéia Rossi |
author_sort | Jessica Calastri, Maria Clara |
collection | PubMed |
description | BACKGROUND: Glioma, most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Evaluate the association of polymorphisms related of to the cell cycle, integrity and DNA repair with gliomas, as well as lifestyle habits, comorbidities, survival and response to treatment. METHODS: Were studied 303 individuals distributed into: Study Group - 100 patients with gliomas, regardless of the degree of malignancy, and Control Group - 203 individuals without clinical signs of the disease. These polymorphisms were genotyped by TaqMan(®) SNP Genotyping Assay. Significance level was set at 5%. RESULTS: Smoking, alcohol consumption, systemic arterial hypertension (SAH) and diabetes mellitus (DM) prevailed in patients, compared to controls (P=0.0088, P=0.0001, P=0.0001, P=0.0011, respectively). In the logistic regression analysis, alcohol consumption and SAH were identified as independent risk factors for gliomas (P=0.0001, P=0.0027, respectively). Patients with low-grade gliomas showed survival in one year (92.0±6.8%), compared to patients with high-grade gliomas (24.0±5.3; P=0.011). CONCLUSION: Polymorphisms involved in cell cycle, telomere protection and stability and DNA repair are not associated with gliomas. On the other hand, alcohol consumption and SAH stand out as independent risk factors for the disease. Low-grade gliomas, response to treatment and the combination of chemotherapy with Temozolomide and radiation therapy show increased survival of patients. |
format | Online Article Text |
id | pubmed-6852820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-68528202019-12-12 Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma Jessica Calastri, Maria Clara Hattori, Gabriela Toledo Ortega Rodrigues, Nicolas Luz Lima Gregório, Michele Oliveira Brancati, Camila Ive Ferreira Milharcix Zanovelo, Eliane Lopes Ferraz Filho, José Roberto Merussi Neiva, Cassiano Ponde Rodrigues Junior, Antonio Carlos de Godoy, Moacir Fernandes Penteado Lancellotti, Carmen Lucia Antonio Tognola, Waldir Silva Souza, Dorotéia Rossi Asian Pac J Cancer Prev Research Article BACKGROUND: Glioma, most common primary malignant brain tumor in adults, is highly aggressive and associated with a poor prognosis. Evaluate the association of polymorphisms related of to the cell cycle, integrity and DNA repair with gliomas, as well as lifestyle habits, comorbidities, survival and response to treatment. METHODS: Were studied 303 individuals distributed into: Study Group - 100 patients with gliomas, regardless of the degree of malignancy, and Control Group - 203 individuals without clinical signs of the disease. These polymorphisms were genotyped by TaqMan(®) SNP Genotyping Assay. Significance level was set at 5%. RESULTS: Smoking, alcohol consumption, systemic arterial hypertension (SAH) and diabetes mellitus (DM) prevailed in patients, compared to controls (P=0.0088, P=0.0001, P=0.0001, P=0.0011, respectively). In the logistic regression analysis, alcohol consumption and SAH were identified as independent risk factors for gliomas (P=0.0001, P=0.0027, respectively). Patients with low-grade gliomas showed survival in one year (92.0±6.8%), compared to patients with high-grade gliomas (24.0±5.3; P=0.011). CONCLUSION: Polymorphisms involved in cell cycle, telomere protection and stability and DNA repair are not associated with gliomas. On the other hand, alcohol consumption and SAH stand out as independent risk factors for the disease. Low-grade gliomas, response to treatment and the combination of chemotherapy with Temozolomide and radiation therapy show increased survival of patients. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6852820/ /pubmed/31450905 http://dx.doi.org/10.31557/APJCP.2019.20.8.2345 Text en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Research Article Jessica Calastri, Maria Clara Hattori, Gabriela Toledo Ortega Rodrigues, Nicolas Luz Lima Gregório, Michele Oliveira Brancati, Camila Ive Ferreira Milharcix Zanovelo, Eliane Lopes Ferraz Filho, José Roberto Merussi Neiva, Cassiano Ponde Rodrigues Junior, Antonio Carlos de Godoy, Moacir Fernandes Penteado Lancellotti, Carmen Lucia Antonio Tognola, Waldir Silva Souza, Dorotéia Rossi Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma |
title | Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma |
title_full | Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma |
title_fullStr | Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma |
title_full_unstemmed | Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma |
title_short | Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma |
title_sort | genetic variants related to cell cycle and stability of telomere in patients with glioma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852820/ https://www.ncbi.nlm.nih.gov/pubmed/31450905 http://dx.doi.org/10.31557/APJCP.2019.20.8.2345 |
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