Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells

Amyloid-β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer’s disease (AD). Tanshinone IIA (Tan IIA), extracted from traditional Chinese herb Radix salvia miltiorrhiza, possesses anti-oxidant and anti-inflammatory actions, as well as neuroprotective effects. The present study...

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Detalles Bibliográficos
Autores principales: Geng, Lijiao, Liu, Wei, Chen, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852914/
https://www.ncbi.nlm.nih.gov/pubmed/31754613
http://dx.doi.org/10.1186/s40709-019-0102-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852914/
https://www.ncbi.nlm.nih.gov/pubmed/31754613
http://dx.doi.org/10.1186/s40709-019-0102-1

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