Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington’s Disease Monkey pluripotent stem cells

BACKGROUND: Huntington’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and significantly contribute to neuronal dysfunction and pathogenesis, the alterations in t...

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Detalles Bibliográficos
Autores principales: Goodnight, Alexandra V., Kremsky, Isaac, Khampang, Sujittra, Jung, Yoon Hee, Billingsley, James M., Bosinger, Steven E., Corces, Victor G., Chan, Anthony W. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852955/
https://www.ncbi.nlm.nih.gov/pubmed/31722751
http://dx.doi.org/10.1186/s13072-019-0313-6

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