Cargando…
Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are pr...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Slovak Toxicology Society SETOX
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853005/ https://www.ncbi.nlm.nih.gov/pubmed/31736636 http://dx.doi.org/10.2478/intox-2018-0020 |
_version_ | 1783469965644398592 |
---|---|
author | Stara, Veronika Mach, Mojmir Ujhazy, Eduard Liptak, Boris Gasparova, Zdenka |
author_facet | Stara, Veronika Mach, Mojmir Ujhazy, Eduard Liptak, Boris Gasparova, Zdenka |
author_sort | Stara, Veronika |
collection | PubMed |
description | Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer΄s disease and dementia. |
format | Online Article Text |
id | pubmed-6853005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Slovak Toxicology Society SETOX |
record_format | MEDLINE/PubMed |
spelling | pubmed-68530052019-11-15 Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration Stara, Veronika Mach, Mojmir Ujhazy, Eduard Liptak, Boris Gasparova, Zdenka Interdiscip Toxicol Original Article Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer΄s disease and dementia. Slovak Toxicology Society SETOX 2018-10 2019-10-18 /pmc/articles/PMC6853005/ /pubmed/31736636 http://dx.doi.org/10.2478/intox-2018-0020 Text en Copyright © 2018 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0) |
spellingShingle | Original Article Stara, Veronika Mach, Mojmir Ujhazy, Eduard Liptak, Boris Gasparova, Zdenka Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration |
title | Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration |
title_full | Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration |
title_fullStr | Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration |
title_full_unstemmed | Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration |
title_short | Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration |
title_sort | beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853005/ https://www.ncbi.nlm.nih.gov/pubmed/31736636 http://dx.doi.org/10.2478/intox-2018-0020 |
work_keys_str_mv | AT staraveronika beneficialeffectof6weekslastinghandlingofadultratsonspatialmemoryinexperimentalmodelofneurodegeneration AT machmojmir beneficialeffectof6weekslastinghandlingofadultratsonspatialmemoryinexperimentalmodelofneurodegeneration AT ujhazyeduard beneficialeffectof6weekslastinghandlingofadultratsonspatialmemoryinexperimentalmodelofneurodegeneration AT liptakboris beneficialeffectof6weekslastinghandlingofadultratsonspatialmemoryinexperimentalmodelofneurodegeneration AT gasparovazdenka beneficialeffectof6weekslastinghandlingofadultratsonspatialmemoryinexperimentalmodelofneurodegeneration |