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Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration

Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are pr...

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Autores principales: Stara, Veronika, Mach, Mojmir, Ujhazy, Eduard, Liptak, Boris, Gasparova, Zdenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853005/
https://www.ncbi.nlm.nih.gov/pubmed/31736636
http://dx.doi.org/10.2478/intox-2018-0020
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author Stara, Veronika
Mach, Mojmir
Ujhazy, Eduard
Liptak, Boris
Gasparova, Zdenka
author_facet Stara, Veronika
Mach, Mojmir
Ujhazy, Eduard
Liptak, Boris
Gasparova, Zdenka
author_sort Stara, Veronika
collection PubMed
description Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer΄s disease and dementia.
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spelling pubmed-68530052019-11-15 Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration Stara, Veronika Mach, Mojmir Ujhazy, Eduard Liptak, Boris Gasparova, Zdenka Interdiscip Toxicol Original Article Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer΄s disease and dementia. Slovak Toxicology Society SETOX 2018-10 2019-10-18 /pmc/articles/PMC6853005/ /pubmed/31736636 http://dx.doi.org/10.2478/intox-2018-0020 Text en Copyright © 2018 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0)
spellingShingle Original Article
Stara, Veronika
Mach, Mojmir
Ujhazy, Eduard
Liptak, Boris
Gasparova, Zdenka
Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
title Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
title_full Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
title_fullStr Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
title_full_unstemmed Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
title_short Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
title_sort beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853005/
https://www.ncbi.nlm.nih.gov/pubmed/31736636
http://dx.doi.org/10.2478/intox-2018-0020
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