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Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration
Melamine-ware is widely used around the world. There is a public health concern as regards the safety of melamine when exposed to food. This study was carried out to measure the level of melamine migration in melamine-ware products by HPLC method and the effect of food-type on the level of melamine...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Slovak Toxicology Society SETOX
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853010/ https://www.ncbi.nlm.nih.gov/pubmed/31762683 http://dx.doi.org/10.2478/intox-2018-0031 |
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author | Haghi, Ehsan Alimohammadi, Mahmood Shakoori, Attaollah Razeghi, Fariba Sadighara, Parisa |
author_facet | Haghi, Ehsan Alimohammadi, Mahmood Shakoori, Attaollah Razeghi, Fariba Sadighara, Parisa |
author_sort | Haghi, Ehsan |
collection | PubMed |
description | Melamine-ware is widely used around the world. There is a public health concern as regards the safety of melamine when exposed to food. This study was carried out to measure the level of melamine migration in melamine-ware products by HPLC method and the effect of food-type on the level of melamine migration. In food control laboratories in Iran, there is no common method to measure and monitor melamine migration, hence a method using HPLC technique was adopted and validated to solve this problem. The validation results showed the reliability with 94.9% accuracy and 95.3% precision. Furthermore, the limit of detection (LOD) and quantification (LOQ) were 0.145 and 0.435 μg/ml, which for a new method were within acceptable ranges. Melamine migrations from 4 most available melamine wares were measured. Distilled water, 3% acetic acid and 15% ethanol were used as food simulant at 30 °C for 90 min. Although melamine migration occurred in all samples and acidic conditions had a significant effect, the values were not higher than the European standard (30 μg/ml). The study revealed that the HPLC method was valid and could be applied and developed to measure melamine migration. However, precautions should be considered while choosing melamine-ware utensil as long-term exposure to this substance has a negative effect on health, especially on the kidneys. |
format | Online Article Text |
id | pubmed-6853010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Slovak Toxicology Society SETOX |
record_format | MEDLINE/PubMed |
spelling | pubmed-68530102019-11-24 Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration Haghi, Ehsan Alimohammadi, Mahmood Shakoori, Attaollah Razeghi, Fariba Sadighara, Parisa Interdiscip Toxicol Original Article Melamine-ware is widely used around the world. There is a public health concern as regards the safety of melamine when exposed to food. This study was carried out to measure the level of melamine migration in melamine-ware products by HPLC method and the effect of food-type on the level of melamine migration. In food control laboratories in Iran, there is no common method to measure and monitor melamine migration, hence a method using HPLC technique was adopted and validated to solve this problem. The validation results showed the reliability with 94.9% accuracy and 95.3% precision. Furthermore, the limit of detection (LOD) and quantification (LOQ) were 0.145 and 0.435 μg/ml, which for a new method were within acceptable ranges. Melamine migrations from 4 most available melamine wares were measured. Distilled water, 3% acetic acid and 15% ethanol were used as food simulant at 30 °C for 90 min. Although melamine migration occurred in all samples and acidic conditions had a significant effect, the values were not higher than the European standard (30 μg/ml). The study revealed that the HPLC method was valid and could be applied and developed to measure melamine migration. However, precautions should be considered while choosing melamine-ware utensil as long-term exposure to this substance has a negative effect on health, especially on the kidneys. Slovak Toxicology Society SETOX 2018-12 2019-10-18 /pmc/articles/PMC6853010/ /pubmed/31762683 http://dx.doi.org/10.2478/intox-2018-0031 Text en Copyright © 2018 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0) |
spellingShingle | Original Article Haghi, Ehsan Alimohammadi, Mahmood Shakoori, Attaollah Razeghi, Fariba Sadighara, Parisa Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration |
title | Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration |
title_full | Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration |
title_fullStr | Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration |
title_full_unstemmed | Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration |
title_short | Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration |
title_sort | measurement of melamine migration from melamine-ware products by designed hplc method and the effect of food-type on the level of migration |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853010/ https://www.ncbi.nlm.nih.gov/pubmed/31762683 http://dx.doi.org/10.2478/intox-2018-0031 |
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