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Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration

Melamine-ware is widely used around the world. There is a public health concern as regards the safety of melamine when exposed to food. This study was carried out to measure the level of melamine migration in melamine-ware products by HPLC method and the effect of food-type on the level of melamine...

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Autores principales: Haghi, Ehsan, Alimohammadi, Mahmood, Shakoori, Attaollah, Razeghi, Fariba, Sadighara, Parisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853010/
https://www.ncbi.nlm.nih.gov/pubmed/31762683
http://dx.doi.org/10.2478/intox-2018-0031
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author Haghi, Ehsan
Alimohammadi, Mahmood
Shakoori, Attaollah
Razeghi, Fariba
Sadighara, Parisa
author_facet Haghi, Ehsan
Alimohammadi, Mahmood
Shakoori, Attaollah
Razeghi, Fariba
Sadighara, Parisa
author_sort Haghi, Ehsan
collection PubMed
description Melamine-ware is widely used around the world. There is a public health concern as regards the safety of melamine when exposed to food. This study was carried out to measure the level of melamine migration in melamine-ware products by HPLC method and the effect of food-type on the level of melamine migration. In food control laboratories in Iran, there is no common method to measure and monitor melamine migration, hence a method using HPLC technique was adopted and validated to solve this problem. The validation results showed the reliability with 94.9% accuracy and 95.3% precision. Furthermore, the limit of detection (LOD) and quantification (LOQ) were 0.145 and 0.435 μg/ml, which for a new method were within acceptable ranges. Melamine migrations from 4 most available melamine wares were measured. Distilled water, 3% acetic acid and 15% ethanol were used as food simulant at 30 °C for 90 min. Although melamine migration occurred in all samples and acidic conditions had a significant effect, the values were not higher than the European standard (30 μg/ml). The study revealed that the HPLC method was valid and could be applied and developed to measure melamine migration. However, precautions should be considered while choosing melamine-ware utensil as long-term exposure to this substance has a negative effect on health, especially on the kidneys.
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spelling pubmed-68530102019-11-24 Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration Haghi, Ehsan Alimohammadi, Mahmood Shakoori, Attaollah Razeghi, Fariba Sadighara, Parisa Interdiscip Toxicol Original Article Melamine-ware is widely used around the world. There is a public health concern as regards the safety of melamine when exposed to food. This study was carried out to measure the level of melamine migration in melamine-ware products by HPLC method and the effect of food-type on the level of melamine migration. In food control laboratories in Iran, there is no common method to measure and monitor melamine migration, hence a method using HPLC technique was adopted and validated to solve this problem. The validation results showed the reliability with 94.9% accuracy and 95.3% precision. Furthermore, the limit of detection (LOD) and quantification (LOQ) were 0.145 and 0.435 μg/ml, which for a new method were within acceptable ranges. Melamine migrations from 4 most available melamine wares were measured. Distilled water, 3% acetic acid and 15% ethanol were used as food simulant at 30 °C for 90 min. Although melamine migration occurred in all samples and acidic conditions had a significant effect, the values were not higher than the European standard (30 μg/ml). The study revealed that the HPLC method was valid and could be applied and developed to measure melamine migration. However, precautions should be considered while choosing melamine-ware utensil as long-term exposure to this substance has a negative effect on health, especially on the kidneys. Slovak Toxicology Society SETOX 2018-12 2019-10-18 /pmc/articles/PMC6853010/ /pubmed/31762683 http://dx.doi.org/10.2478/intox-2018-0031 Text en Copyright © 2018 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0)
spellingShingle Original Article
Haghi, Ehsan
Alimohammadi, Mahmood
Shakoori, Attaollah
Razeghi, Fariba
Sadighara, Parisa
Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration
title Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration
title_full Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration
title_fullStr Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration
title_full_unstemmed Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration
title_short Measurement of melamine migration from melamine-ware products by designed HPLC method and the effect of food-type on the level of migration
title_sort measurement of melamine migration from melamine-ware products by designed hplc method and the effect of food-type on the level of migration
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853010/
https://www.ncbi.nlm.nih.gov/pubmed/31762683
http://dx.doi.org/10.2478/intox-2018-0031
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