Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition

The Epidermal Growth Factor Receptor (EGFR) and the Transforming Growth Factor-beta (TGF-β) are key regulators of hepatocarcinogenesis. Targeting EGFR was proposed as a promising therapy; however, poor success was obtained in human hepatocellular carcinoma (HCC) clinical trials. Here, we describe ho...

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Detalles Bibliográficos
Autores principales: López-Luque, Judit, Bertran, Esther, Crosas-Molist, Eva, Maiques, Oscar, Malfettone, Andrea, Caja, Laia, Serrano, Teresa, Ramos, Emilio, Sanz-Moreno, Victoria, Fabregat, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853171/
https://www.ncbi.nlm.nih.gov/pubmed/31465839
http://dx.doi.org/10.1016/j.canlet.2019.08.011

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