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Risk factors and outcomes of acute kidney injury in ventilated newborns

Purpose: This study aimed to investigate the occurrence and risk factors of acute kidney injury (AKI) in ventilated newborns. Methods: In total, 139 newborns receiving mechanical ventilation (MV) were reviewed in this retrospective study. The demographic and clinical data were collected. Then, the i...

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Autores principales: Fan, Yuanyuan, Ye, Jinkun, Qian, Lijuan, Zhao, Ruibin, Zhang, Ning, Xue, Liwen, Qiao, Lixing, Jiang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853215/
https://www.ncbi.nlm.nih.gov/pubmed/31698978
http://dx.doi.org/10.1080/0886022X.2019.1665546
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author Fan, Yuanyuan
Ye, Jinkun
Qian, Lijuan
Zhao, Ruibin
Zhang, Ning
Xue, Liwen
Qiao, Lixing
Jiang, Li
author_facet Fan, Yuanyuan
Ye, Jinkun
Qian, Lijuan
Zhao, Ruibin
Zhang, Ning
Xue, Liwen
Qiao, Lixing
Jiang, Li
author_sort Fan, Yuanyuan
collection PubMed
description Purpose: This study aimed to investigate the occurrence and risk factors of acute kidney injury (AKI) in ventilated newborns. Methods: In total, 139 newborns receiving mechanical ventilation (MV) were reviewed in this retrospective study. The demographic and clinical data were collected. Then, the independent risk factors for AKI were evaluated using univariate and multivariate logistic regression analyses. Results: The incidence rate of AKI was 15.11% (21/139) in ventilated newborns. Univariate analysis showed significant differences in gestational age, birth weight, Apagar scores, the highest oxygen concentration, serum creatinine levels at admission and 48 h after MV, history of asphyxia, urine output at 48 h after MV, invasive MV, noninvasive MV, and outcomes between AKI and non-AKI groups (all p < .05). The lower gestational age (odd ratio (OR): 1.194, 95% confidence interval (CI): 1.013–1.407, p = .035), the increased use of invasive mechanical ventilation (IMV) (OR: 4.790, 95% CI: 1.115–20.575, p = .035), and lower birth weight (OR: 0.377, 95% CI: 0.178–0.801, p = .011) were independent risk factors for the occurrence of AKI. Additionally, higher stage of AKI was significantly associated with poor prognosis of AKI (p = .018). Conclusion: In this retrospective study, it was found that lower gestational age, birth weight, and increased use of IMV were independent risk factors for AKI in ventilated newborns. The poor prognosis might be indicated by the higher AKI stage.
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spelling pubmed-68532152019-11-22 Risk factors and outcomes of acute kidney injury in ventilated newborns Fan, Yuanyuan Ye, Jinkun Qian, Lijuan Zhao, Ruibin Zhang, Ning Xue, Liwen Qiao, Lixing Jiang, Li Ren Fail Clinical Study Purpose: This study aimed to investigate the occurrence and risk factors of acute kidney injury (AKI) in ventilated newborns. Methods: In total, 139 newborns receiving mechanical ventilation (MV) were reviewed in this retrospective study. The demographic and clinical data were collected. Then, the independent risk factors for AKI were evaluated using univariate and multivariate logistic regression analyses. Results: The incidence rate of AKI was 15.11% (21/139) in ventilated newborns. Univariate analysis showed significant differences in gestational age, birth weight, Apagar scores, the highest oxygen concentration, serum creatinine levels at admission and 48 h after MV, history of asphyxia, urine output at 48 h after MV, invasive MV, noninvasive MV, and outcomes between AKI and non-AKI groups (all p < .05). The lower gestational age (odd ratio (OR): 1.194, 95% confidence interval (CI): 1.013–1.407, p = .035), the increased use of invasive mechanical ventilation (IMV) (OR: 4.790, 95% CI: 1.115–20.575, p = .035), and lower birth weight (OR: 0.377, 95% CI: 0.178–0.801, p = .011) were independent risk factors for the occurrence of AKI. Additionally, higher stage of AKI was significantly associated with poor prognosis of AKI (p = .018). Conclusion: In this retrospective study, it was found that lower gestational age, birth weight, and increased use of IMV were independent risk factors for AKI in ventilated newborns. The poor prognosis might be indicated by the higher AKI stage. Taylor & Francis 2019-11-07 /pmc/articles/PMC6853215/ /pubmed/31698978 http://dx.doi.org/10.1080/0886022X.2019.1665546 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Fan, Yuanyuan
Ye, Jinkun
Qian, Lijuan
Zhao, Ruibin
Zhang, Ning
Xue, Liwen
Qiao, Lixing
Jiang, Li
Risk factors and outcomes of acute kidney injury in ventilated newborns
title Risk factors and outcomes of acute kidney injury in ventilated newborns
title_full Risk factors and outcomes of acute kidney injury in ventilated newborns
title_fullStr Risk factors and outcomes of acute kidney injury in ventilated newborns
title_full_unstemmed Risk factors and outcomes of acute kidney injury in ventilated newborns
title_short Risk factors and outcomes of acute kidney injury in ventilated newborns
title_sort risk factors and outcomes of acute kidney injury in ventilated newborns
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853215/
https://www.ncbi.nlm.nih.gov/pubmed/31698978
http://dx.doi.org/10.1080/0886022X.2019.1665546
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